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human homolog interacts with Ring1 and localizes to nuclear Polycomb bodies [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen CBX7 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 (zeige PRC1 Antikörper) complex to chromatin.
these results of this study suggest that CBX7 deficiency plays a positive role in dentin and alveolar bone formation.
CD4 (zeige CD4 Antikörper)(+) T cells express Cbx7; the latter prevents FasL (zeige FASL Antikörper) expression and the activation-induced CD4 (zeige CD4 Antikörper)(+) T cell apoptosis.
Threonine 118 is a novel phosphorylation site of mouse Cbx7. Cbx7T118 phosphorylation moderately enhances repression of its target gene p16.
Although the genomic localization of the Cbx7- and RYBP (zeige RYBP Antikörper)-containing PRC1 (zeige PRC1 Antikörper) complexes overlaps in certain genes, it can also be mutually exclusive.
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.
These data suggest that CBX7 is a tumor suppressor and that its loss plays a key role in the pathogenesis of cancer.
controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 (zeige TP53 Antikörper) pathways
CBX7 is a chromobox protein causally linked to cancer development
Study found that Cbx7 was downregulated in glioma cell lines and tumors and identifies it as an inhibitor of glioma cell migration through its inhibitory effect on YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper)-CTGF (zeige CTGF Antikörper)-hippo signaling axis and underscores the importance of epigenetic inactivation of Cbx7 in gliomagenesis.
CBX7 inhibits epithelial-to-mesenchymal transformation and invasion in glioma
our results validate the assumption that CBX7 is a tumor suppressor of gliomas. Moreover, CBX7 is a potential and novel prognostic biomarker in glioma patients. We also clarified that CBX7 silences CCNE1 (zeige CCNE1 Antikörper) via the combination of CCNE1 (zeige CCNE1 Antikörper) promoter and the recruitment of HDAC2 (zeige HDAC2 Antikörper).
Suggest CBX7 is an important tumor suppressor that negatively modulates PTEN/Akt (zeige AKT1 Antikörper) signaling during pancreatic tumorigenesis.
Data suggest that miR (zeige MLXIP Antikörper)-375 leads to the activation of oncogenic signatures and tumor progression by targeting chromobox homolog 7 protein (CBX7).
the miR (zeige MLXIP Antikörper)-9 family of microRNAs (miRNAS) downregulates the expression of CBX7. In turn, CBX7 represses miR (zeige MLXIP Antikörper)-9-1 and miR (zeige MLXIP Antikörper)-9-2 as part of a regulatory negative feedback loop.
these results suggest that the retention of CBX7 expression may play a role in the modulation of chemosensitivity of lung cancer patients to the treatment with irinotecan and etoposide
Data show that polycomb (zeige CBX2 Antikörper)-group proteins BMI1 (zeige BMI1 Antikörper), PHC3 (zeige PHC3 Antikörper), CBX6 (zeige CBX6 Antikörper) and CBX7 expression was significantly increased during imatinib treatment.
Cbx7 is downregulated in CCs (zeige CCS Antikörper), and Cbx7 expression-low tumors correlated with lymph metastasis and poor overall survival of CC patients.
CBX7/HMGA1b (zeige HMGA1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) could take part in the same transcriptional mechanism that finally leads to the regulation of SPP1 (zeige SPP1 Antikörper) gene expression in papillary thyroid carcinoma.
human homolog interacts with Ring1 and localizes to nuclear Polycomb bodies
chromobox homolog 7
, chromobox protein homolog 7
, chromobox 7
, chromobox homolog 7a