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Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]..
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Human Monoclonal CHAF1A Primary Antibody für ICC, IF - ABIN153013
Smith, Stillman: Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro. in The Journal of biological chemistry 1991
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Monoclonal CHAF1A Primary Antibody für IF, IP - ABIN534079
Shibahara, Stillman: Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. in Cell 1999
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Human Monoclonal CHAF1A Primary Antibody für ICC, IF - ABIN2668347
Hoek, Stillman: Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human Monoclonal CHAF1A Primary Antibody für ELISA, WB - ABIN564324
Doe, Nozawa, Hiruma, Yamada, Matsuki, Nakano, Ogasawara, Nakano, Ikeda, Ikegami, Fujishiro, Kawasaki, Ikeda, Amano, Morimoto, Ogawa, Takamori, Sekigawa, Takasaki: Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. in Lupus 2014
Recent work has identified the chromatin assembly factor complex CAF-1 (zeige CHAF1B Antikörper) as a potent barrier to cellular reprogramming. In addition, CAF-1 (zeige CHAF1B Antikörper) has been implicated in the reversion of pluripotent cells to a totipotent-like state and in various lineage conversion paradigms, suggesting that modulation of CAF-1 (zeige CHAF1B Antikörper) levels may endow cells with a developmentally more plastic state.
Chromatin reassembly during double-strand break repair was dependent on the HIRA histone chaperone that is specific to the replication-independent histone variant H3.3 and on CAF-1 that is specific to the replication-dependent canonical histones H3.1/H3.2.
Data show that the high expression of chromatin assembly factor 1 (zeige RBBP4 Antikörper), subunit A (p150) (CHAF1A) promotes cell proliferation and inhibits cell apoptosis, suggesting that CHAF1A may be developed as a prognosis biomarker and potential therapeutic target of epithelial ovarian cancer (EOC).
CHAF1A inhibits NEIL1 (zeige NEIL1 Antikörper) initiated repair in vitro Subsequent restoration of the chaperone-BER complex in cell, presumably after completion of repair, suggests that histone chaperones sequester the repair complex for oxidized bases in non-replicating chromatin, and allow repair when oxidized bases are induced in the genome.
Loss of CAF1 is associated with increased motility and invasive phenotypes seen in transformed cells.
These data suggest that CAF-1 (zeige CHAF1B Antikörper)- and ASF1A (zeige ASF1A Antikörper)-H3-H4-dependent deposition of the histone (H3 (zeige HIST3H3 Antikörper)-H4)2 tetramers is compatible with MMR (zeige MRC1 Antikörper) and protects the discontinuous daughter strand from unnecessary degradation by MMR (zeige MRC1 Antikörper) machinery.
Taken together, these results show that CHAF1A contributes to the proliferation of glioblastoma cells and may be developed as a de novo drug target and prognosis biomarker of glioblastoma.
Novel functions for a separable domain of the p150 (zeige ABL1 Antikörper) protein, regulating protein and DNA interactions at the nucleolus.
The frequency of positive CHAF1A staining in primary tumor mucosa (45.8% of 203 samples) was significantly elevated compared to normal mucosa (18.7% of samples). Increased expression was associated with cancer stage, tumor invasion and histological grade.
Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma (zeige ARHGEF16 Antikörper).
CAF-1 (zeige CNOT7 Antikörper) is an essential guardian of the genome in preimplantation mouse embryos.
the histone chaperone CAF-1 (zeige CNOT7 Antikörper) to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting
Findings suggest that p150 may link the DNA-bound Gfi1 repressor complex to histones enabling modifications required for transcriptional silencing.
This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1 (zeige RBBP4 Antikörper)), and its ability to interact with HP1alpha (zeige CBX5 Antikörper).
during DNA replication, the interaction of HP1 (zeige CBX5 Antikörper) with p150CAF-1 is essential to promote delivery of HP1 (zeige CBX5 Antikörper) molecules to heterochromatic sites
findings suggest that CAF-1 (zeige CNOT7 Antikörper) is required for the maturation of heterochromatin during preimplantation development (zeige MTA2 Antikörper) and that CAF-1 (zeige CNOT7 Antikörper) is specifically required for heterochromatin organization in pluripotent embryonic cells
Data show that human CAF-1 (p150) contains two PCNA (zeige PCNA Antikörper) interaction peptides, and suggest that these peptides are part of the mechanism that enables CAF-1 (zeige CNOT7 Antikörper) to function behind replication forks without interfering with other PCNA (zeige PCNA Antikörper)-mediated processes.
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995
chromatin assembly factor 1, subunit A (p150)
, chromatin assembly factor 1 subunit A-like
, CAF-1 subunit A
, CAF-I 150 kDa subunit
, CAF-I p150
, chromatin assembly factor 1 subunit A
, chromatin assembly factor I (150 kDa)
, chromatin assembly factor I p150 subunit
, chromatin assembly factor-1p150
, Chromatin assembly factor I p150 subunit
, CAF-I 150 kDa subunit B
, CAF-I p150-B
, Chromatin assembly factor I p150 subunit B
, chromatin assembly factor 1 subunit A-B