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Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls.
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Human Monoclonal CHI3L1 Primary Antibody für ELISA - ABIN2472953
Iwarson: [The pattern of non-A, non-B hepatitis is more and more evident. A new test for diagnosis of hepatitis C makes it possible to mass screen blood donors]. in Läkartidningen 1990
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Cow (Bovine) Polyclonal CHI3L1 Primary Antibody für IF, WB - ABIN2784693
Ober, Tan, Sun, Possick, Pan, Nicolae, Radford, Parry, Heinzmann, Deichmann, Lester, Gern, Lemanske, Nicolae, Elias, Chupp: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. in The New England journal of medicine 2008
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miR (zeige MLXIP Antikörper)-24 serves as a molecular regulator in S. aureus-induced macrophage polarization through targeting of CHI3L1 and regulation of the MAPK (zeige MAPK1 Antikörper) pathway
The mouse model was used to validate the function of CHI3L1 in cancer metastasis in vivo
CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (zeige S100A9 Antikörper) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (zeige S100A9 Antikörper) receptor, RAGE (zeige AGER Antikörper) (Receptor for Advanced Glycation End products).
IL-18 (zeige IL18 Antikörper) is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18 (zeige IL18 Antikörper)-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.
CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.
Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.
Results do not support a role of BRP (zeige GDF5 Antikörper)-39 in the pathogenesis of experimental autoimmune encephalitis.
CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.
mechanism of BRP (zeige GDF5 Antikörper)-39 in bleomycin-induced pulmonary fibrosis
Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis
YKL-40 could be considered as a useful biomarker of inflammation in psoriasis and is more sensitive than CRP (zeige CRP Antikörper) or WBC. Increased YKL-40 may indicate psoriatic patients with a higher level of systemic inflammation, which may determine disease management.
YKL-40 protein expression associated with severe lung function impairment and severe exacerbations in Asthma patients.
Results suggest a potential role of chitinase 3 like 1 protein (CHI3L1) in angiogenesis in invasive ductal breast carcinoma (IDC (zeige LMNA Antikörper)) and may suggest its involvement in cancer progression.
YKL-40 is a promising biomarker for evaluating polymyositis/dermatomyositis-associated interstitial lung disease activity/severity and predicting disease prognosis.
Early-onset atopic dermatitis was associated with rs2303067 in SPINK5 (zeige SPINK5 Antikörper), which is involved in skin barrier functioning, and late-onset was associated with rs4950928 in CHI3L1, which is involved in the immune response. Future studies should examine the early- versus late-onset subgrouping more closely.
YKL-40 may represent a novel biomarker for predicting hypertension risk in prehypertension population
A high diagnostic sensitivity of YKL-40 in the early stages of the disease suggests the possibility of using this biomarker at an early diagnostic phase of patients with endometrial cancer. The patients with increased levels of YKL-40 before treatment are also at the higher risk of relapse.
Serum YKL-40 was elevated only in atrial fibrllation and not in other supraventricular arrhythmias.
YKL-40 is elevated in serum and bronchoalveolar lavage fluid of pulmonary alveolar proteinosis (PAP (zeige REG3A Antikörper)) patients, and may be of clinical utility to predict outcome in PAP (zeige REG3A Antikörper)
YKL-40 was expressed by macrophages in liver tissue of NAFLD (zeige TSC2 Antikörper) patients.
chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
, cartilage glycoprotein 39
, chitinase-3-like protein 1
, 39 kDa synovial protein
, 38 kDa heparin-binding glycoprotein
, signal-processing protein
, 39 kDa whey protein
, 40 kDa secretory signalling glycoprotein
, cartilage glycoprotein-39
, chitinase-like protein 1
, signal processing protein
, chitinase 3-like 1 protein
, mammary gland protein 40