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CCRL2 encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1.
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Human Monoclonal CCRL2 Primary Antibody für CyTOF, FACS - ABIN4899082
Hartmann, Leick, Ewers, Diefenbacher, Schraufstatter, Honczarenko, Burger: Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. in Immunology 2008
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Human Monoclonal CCRL2 Primary Antibody für CyTOF, FACS - ABIN4899081
Leick, Catusse, Follo, Nibbs, Hartmann, Veelken, Burger: CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. in Immunology 2010
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CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients.
CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo.
in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response.
these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion.
Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation.
demonstration that the homeostatic chemokine CCL19 (zeige CCL19 Antikörper) is a specific ligand for CRAM
CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients
Results identify chemerin (zeige RARRES2 Antikörper) as a natural nonsignaling protein ligand for both human and mouse CCRL2.
upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2 (zeige CXCR2 Antikörper)-mediated neutrophil recruitment at sites of inflammation.
chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.
CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 was related to the mRNA levels of F4/80, transforming growth factor beta and alpha smooth muscle actin (zeige ACTG2 Antikörper) in murine non-alcoholic steatohepatitis.
Proinflammatory stimuli upregulate atypical chemerin receptor (zeige CMKLR1 Antikörper) CCRL2 and VCAM-1 (zeige VCAM1 Antikörper) on endothelial cells via NF-kappaB (zeige NFKB1 Antikörper) and JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) intracellular signaling pathways.
Ccrl2(-/-) mice showed normal recruitment of circulating dendritic cells (DC) into the lung, but a defective trafficking of antigen-loaded lung DC to mediastinal lymph nodes.
Expression of L-CCR mRNA is reported in murine astrocytes and microglia and is greatly enhanced under proinflammatory conditions; this receptor may play a role in neuroinflammatory processes.
Prominent expression of L-CCR mRNA is detected in astrocytes and microglia at early time points throughout the brain and spinal cord in experimental autoimmune encephalomyelitis supporting the proposed relationship of L-CCR expression to CNS inflammation.
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.
C-C chemokine receptor-like 2
, chemokine (C-C motif) receptor-like 2
, c-C chemokine receptor-like 2-like
, atypical chemokine receptor 5
, chemokine receptor CCR11
, chemokine receptor X
, putative MCP-1 chemokine receptor
, G-protein coupled beta chemokine receptor
, chemokine (C-C) receptor 1,-like 2
, chemokine (C-C) receptor 1-like 2
, lipopolysaccharide inducible C-C chemokine receptor related
, lipopolysaccharide-inducible C-C chemokine receptor
, lipopolysacharide-inducible C-C chemokine receptor
, chemokine C-C motif receptor-like 2