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The protein encoded by CASZ1 is a zinc finger transcription factor.
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Cow (Bovine) Polyclonal CASZ1 Primary Antibody für WB - ABIN2777772
Fernandez, Curtain, Colson, Ovcaric, MacMillan, Griffiths: Association analysis of chromosome 1 migraine candidate genes. in BMC medical genetics 2007
CHD5 is essential for CASZ1 function and the CHD5-CASZ1 interaction is necessary for cardiac morphogenesis
CASZ1/Egfl7/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
Data report that Xenopus CASTOR affects cardiogenesisis, and is required for differentiation of cardiac precursor cells at the ventral midline.
Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)
These findings provide insight into mechanisms by which CASZ1 regulates transcription, and suggests that regulation of CASZ1 subcellular localization may impact its function in normal development and pathologic conditions such as NB tumorigenesis.
The current study reveals CASZ1 as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel mechanistic insight and potential therapeutic target for CASZ1-associated DCM, implying potential implications in improved prophylactic and therapeutic strategies for DCM, the most common type of primary myocardial disease.
the current study firstly identifies CASZ1 as a new gene predisposing to congenital heart disease in humans
CASZ1b binds to chromatin and recruits NuRD complexes to orchestrate epigenetic-mediated transcriptional programs
CASZ1 inhibits cell cycle progression in neuroblastoma by restoring retinoblastoma protein activity.
Papillomavirus DNA integration is associated with loss of CASZ1 gene and thus cervical carcinogenesis.
This study identifies key domains needed for CASZ1b to regulate gene transcription; a link between loss of CASZ1b transcriptional activity and attenuation of CASZ1b-mediated inhibition of neuroblastoma growth and tumorigenicity
determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells
CASZ1 is a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human Neuroblastoma.
The study indicates that although their mechanisms of regulation may be distinct, both CASZ1b and CASZ1a have largely redundant but critical roles in suppressing tumor cell growth.
CASZ1 is expressed in a number of human tumors and localizes to a chromosomal region frequently lost in tumors of neuroectodermal origin.
these data support a model in which Casz1 cooperates with polycomb to control rod genome organization, in part by silencing lamin A/C.
Study shows that Casz1 lies downstream of Prrxl1 in the differentiation pathway of a large subset of dorsal late-born excitatory neurons and provides a framework for further studies of Casz1 in assembly of the dorsal root ganglion-spinal circuit.
these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields.
Casz1 is expressed from mid/late stages in retinal progenitor cells.
Abnormal expression of cardiac morphogenesis and contraction genes induced by loss of Casz1 contributes to the heart defect.
report the expression pattern of a murine Castor related gene (Cst) during embryogenesis [cst]
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
castor zinc finger 1
, castor homolog 1, zinc finger
, zinc finger protein castor homolog 1-like
, castor-related protein
, zinc finger protein 693
, zinc finger protein castor homolog 1