CUB Domain Containing Protein 1 Proteine (CDCP1)

The protein encoded by CDCP1 is a transmembrane protein containing three extracellular CUB domains. Zusätzlich bieten wir Ihnen CUB Domain Containing Protein 1 Antikörper (195) und CUB Domain Containing Protein 1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CDCP1 64866 Q9H5V8
CDCP1 109332 Q5U462
Ratte CDCP1 CDCP1 301082  
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Top CUB Domain Containing Protein 1 Proteine auf

Showing 10 out of 19 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Human Cells Maus His tag 50 μg 14 bis 16 Tage
Human Cells Human Fc Tag 50 μg 14 bis 16 Tage
Human Cells Rhesusaffen His tag 100 μg 14 bis 16 Tage
Baculovirus infected Insect Cells Human His tag 50 μg 13 bis 16 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
Human Cells Human His tag   50 μg 4 Days
Human Cells Human His tag   10 μg 15 bis 16 Tage

CDCP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , , , ,
Mouse (Murine) ,
, ,

Am meisten referenzierte CUB Domain Containing Protein 1 Proteine

  1. Human CDCP1 Protein expressed in HEK-293 Cells - ABIN2713643 : Sandercock, Rust, Guillard, Sachsenmeier, Holoweckyj, Hay, Flynn, Huang, Yan, Herpers, Price, Soden, Freeth, Jermutus, Hollingsworth, Minter: Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling. in Molecular cancer 2015 (PubMed)

Weitere Proteine zu CUB Domain Containing Protein 1 (CDCP1) Interaktionspartnern

Human CUB Domain Containing Protein 1 (CDCP1) Interaktionspartner

  1. The CDCP1 is cleaved by serine proteases at adjacent sites, arginine 368 (R368) and lysine 369 (K369), which induces cell migration in vitro and metastasis in vivo.

  2. CDCP1 was the most significant (FDR adjusted p-value 0.006). Correlation with CDCP1 concentration was most significant for CD34+ concentration and nucleated cell count. Multivariate analysis showed that CD34 and gender seemed to influence the level of CDCP1.

  3. Study discovered a new mechanism of regulation of CDK5 through loss of CDCP1, which dynamically regulates beta1-integrin in non-adherent cells and which may promote vascular dissemination in patients with advanced prostate cancer.

  4. Study identified PDGF-BB/PDGFRbeta-mediated pathway as a novel player in the regulation of CDCP1 in triple-negative breast cancer through ERK1/2 activation.

  5. Low CDCP1 expression is associated with idiopathic pulmonary fibrosis.

  6. Expression of CDCP1 was reduced by AHCC treatment of KLM1-R cells, whereas expression of actin was not affected. The ratio of intensities of CDCP1/actin in AHCC-treated KLM1-R cells was significantly suppressed (p<0.05) compared to untreated cells.

  7. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing.

  8. CDCP1 knockdown reduced 3D invasion, which can be rescued by ACSL3 co-knockdown. In vivo, inhibiting CDCP1 activity with an engineered blocking fragment (extracellular portion of cleaved CDCP1) lead to increased LD abundance in primary tumors, decreased metastasis, and increased ACSL activity in two animal models of TNBC.

  9. These results revealed that ADAM9 down-regulates miR-1 via activating EGFR signaling pathways, which in turn enhances CDCP1 expression to promote lung cancer progression.

  10. CDCP1 is a novel marker of the most aggressive N-positive triple-negative breast cancers; CDCP1 expression and gains in CDCP1 copy number synergized with nodal (N) status in determining disease-free and distant disease-free survival

  11. High expression level of CDCP1 is associated with recurrence in glioblastoma.

  12. These studies have important implications for the development of a therapeutic to block CDCP1 activity and Triple-negative breast cancer (TNBC)metastasis.

  13. CDCP1 may facilitate loss of adhesion by promoting activation of EGFR and Src at sites of cell-cell and cell-substratum contact.

  14. Stromal expression patterns for both ADAM12 and CDCP1.

  15. these data demonstrated that HIF-2alpha could promote hepatocellular carcinoma cell migration by regulating CDCP1

  16. Our results establish that differential glycosylation, cell surface presentation and extracellular expression of CDCP1 are hallmarks of prostate cancer progression.

  17. High CDCP1 expression is associated with Colorectal Cancer.

  18. ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis

  19. Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo.

  20. CDCP1 protein plays an important role in the progression of ovarian clear cell carcinoma. Elevated CDCP1 levels correlates with poor patient outcome in ovarian clear cell carcinoma patients.

Mouse (Murine) CUB Domain Containing Protein 1 (CDCP1) Interaktionspartner

  1. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases.

  2. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.

  3. established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 cleavage and PARP1-mediated apoptosis

  4. CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model

CUB Domain Containing Protein 1 (CDCP1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Genbezeichner und Symbole assoziert mit CDCP1

  • CUB domain containing protein 1 (CDCP1)
  • CUB domain containing protein 1 (Cdcp1)
  • CUB domain containing protein 1a (cdcp1a)
  • 9030022E12Rik Protein
  • AA409659 Protein
  • CD318 Protein
  • E030027H19Rik Protein
  • RGD1305578 Protein
  • SIMA135 Protein
  • TRASK Protein
  • zgc:113071 Protein

Bezeichner auf Proteinebene für CDCP1

CUB domain-containing protein 1 , membrane glycoprotein gp140 , subtractive immunization M plus HEp3-associated 135 kDa protein , transmembrane and associated with src kinases

64866 Homo sapiens
109332 Mus musculus
484797 Canis lupus familiaris
301082 Rattus norvegicus
420703 Gallus gallus
100065703 Equus caballus
739085 Pan troglodytes
100450442 Pongo abelii
541520 Danio rerio
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