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The protein encoded by CDCP1 is a transmembrane protein containing three extracellular CUB domains. Zusätzlich bieten wir Ihnen CUB Domain Containing Protein 1 Antikörper (202) und CUB Domain Containing Protein 1 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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Human CDCP1 Protein expressed in HEK-293 Cells - ABIN2713643
Sandercock, Rust, Guillard, Sachsenmeier, Holoweckyj, Hay, Flynn, Huang, Yan, Herpers, Price, Soden, Freeth, Jermutus, Hollingsworth, Minter: Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling. in Molecular cancer 2015
Co-expression of CDCP1 and AXL (zeige AXL Proteine) is often observed in EGFR (zeige EGFR Proteine)-mutation-positive tumors, limiting the efficacy of EGFR (zeige EGFR Proteine) TKIs. Co-treatment with EGFR (zeige EGFR Proteine) TKI and TPX (zeige TPO Proteine)-0005 warrants testing.
CDCP1 knockdown reduced 3D invasion, which can be rescued by ACSL3 (zeige Acsl3 Proteine) co-knockdown. In vivo, inhibiting CDCP1 activity with an engineered blocking fragment (extracellular portion of cleaved CDCP1) lead to increased LD abundance in primary tumors, decreased metastasis, and increased ACSL activity in two animal models of TNBC.
These results revealed that ADAM9 (zeige ADAM9 Proteine) down-regulates miR-1 (zeige FSD1 Proteine) via activating EGFR (zeige EGFR Proteine) signaling pathways, which in turn enhances CDCP1 expression to promote lung cancer progression.
CDCP1 is a novel marker of the most aggressive N-positive triple-negative breast cancers; CDCP1 expression and gains in CDCP1 copy number synergized with nodal (N) status in determining disease-free and distant disease-free survival
High expression level of CDCP1 is associated with recurrence in glioblastoma.
These studies have important implications for the development of a therapeutic to block CDCP1 activity and Triple-negative breast cancer (TNBC)metastasis.
CDCP1 may facilitate loss of adhesion by promoting activation of EGFR (zeige EGFR Proteine) and Src (zeige SRC Proteine) at sites of cell-cell and cell-substratum contact.
Stromal expression patterns for both ADAM12 (zeige ADAM12 Proteine) and CDCP1.
these data demonstrated that HIF-2alpha (zeige EPAS1 Proteine) could promote hepatocellular carcinoma cell migration by regulating CDCP1
Our results establish that differential glycosylation, cell surface presentation and extracellular expression of CDCP1 are hallmarks of prostate cancer progression.
Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6 (zeige CD6 Proteine)) and a potential target for the diagnosis and treatment of autoimmune diseases.
Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor (zeige RYK Proteine) cross-talk in unanchored cells.
established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 (zeige PARP1 Proteine) cleavage and PARP1 (zeige PARP1 Proteine)-mediated apoptosis
CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model
The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
CUB domain-containing protein 1
, membrane glycoprotein gp140
, subtractive immunization M plus HEp3-associated 135 kDa protein
, transmembrane and associated with src kinases