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CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. Zusätzlich bieten wir Ihnen CD68 Antikörper (742) und CD68 Kits (34) und viele weitere Produktgruppen zu diesem Protein an.
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Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.
Myeloid osteoclast precursors do not express CD68.
CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.
Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age
Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 (zeige CCR7 Proteine) / CD68 emigration pathway in macrophages
These findings demonstrate a role for CD68 in the function of osteoclasts.
CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking.
Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques.
Macrosialin does not function as an oxLDL receptor on the cell surface.
Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice.
A combination of CD68/CD206 (zeige MRC1 Proteine) density and HBV-positivity improves further predictive value for post-operative recurrence of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) . Quantification of CD68/CD206 (zeige MRC1 Proteine) macrophages and their distribution can be exploited for better postsurgical management of HCC (zeige FAM126A Proteine) patients.
Report CD68 over-expression in multinucleated giant cells and mononuclear cells in central and peripheral giant cell granuloma of jaw.
This study shown the CD68 expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.
The results of this study found that the expression levels of Cd68 and Atp5b (zeige ATP5B Proteine) were significantly correlated with the neurofibrillary tangle burden in the Alzheimer's Disease brain and with their cognition.
Taken together, these results suggested that the changes, including ox-LDL/LDL ratio, CD68(+)/RANK(+) cells number, and the levels of RANKL (zeige TNFSF11 Proteine) and HMGB1 (zeige HMGB1 Proteine) in AS patients, favored osteoclastogenesis.
High expression of CD68 is associated with nonalcoholic steatohepatitis.
increased amount of CD68+TAM (zeige CCNA1 Proteine) in gaps of ductal tumor structures is protective against metastatic spread in regional lymph nodes.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (6 of 7 cases), CD163 (zeige CD163 Proteine) (5 of 5 cases), and PU.1 (3 of 4 cases).
Renal expression of CD68 and the chronicity index are associated with progression to chronic kidney disease in patients with proliferative lupus nephritis.
Results indicate that the expression of FoxP3 (zeige FOXP3 Proteine) was not significantly associated with survival, and suggest prognostic significance of high CD68 expression in primary central nervous system lymphoma (PCNSL).
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
, CD68 antigen
, macrophage antigen CD68
, scavenger receptor class D, member 1