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CD68 Protein (His tag)

CD68 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Produktnummer ABIN7321138
  • Target Alle CD68 Proteine anzeigen
    CD68 (CD68 Molecule (CD68))
    Protein-Typ
    Recombinant
    Spezies
    • 11
    • 5
    • 2
    Ratte
    Quelle
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD68 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Rat CD68/Macrosialin Protein (His Tag)
    Sequenz
    Met1-Ser295
    Produktmerkmale
    A DNA sequence encoding the rat CD68 (Q4FZY1) (Met1-Ser295) was expressed, fused with a polyhistidine tag at the C-terminus.
    Reinheit
    > 95 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product CD68 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CD68 (CD68 Molecule (CD68))
    Andere Bezeichnung
    CD68/Macrosialin (CD68 Produkte)
    Synonyme
    Lamp4 Protein, Scard1 Protein, gp110 Protein, GP110 Protein, LAMP4 Protein, SCARD1 Protein, CD68 molecule Protein, CD68 antigen Protein, Cd68 molecule Protein, CD68 Protein, Cd68 Protein
    Hintergrund

    Background: Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

    Synonym: CD68

    Molekulargewicht
    30.9 kDa
    UniProt
    Q4FZY1
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