anti-CD2-Associated Protein (Cd2ap) Antikörper

Zebrafish CD2-Associated Protein (Cd2ap) Interaktionspartner

1. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

Human CD2-Associated Protein (Cd2ap) Interaktionspartner

1. Study identified a homozygous frameshift mutation in CD2AP (p.S198fs) in three siblings born of consanguineous parents who developed childhood-onset focal segmental glomerulosclerosis (FSGS) and end stage renal disease. When the same mutation was introduced in mice by gene editing, the mice developed FSGS and kidney failure. These results provide conclusive evidence that homozygous mutation of CD2AP causes FSGS in humans.

2. PAWS1 interacts in a dynamic fashion with the actin/cytoskeletal regulator CD2AP at lamellae, suggesting that its association with CD2AP controls actin organization and cellular migration. Genetic ablation of CD2AP from U2OS cells instigates actin and cell migration defects reminiscent of those seen in PAWS1-knockout cells.

3. CD2AP is indicated as a protein up-regulated by HCV infection, which, in turn, stimulates HCV propagation and steatosis by disrupting insulin signaling; targeting CD2AP may offer an opportunity for alleviating HCV infection and its associated liver pathology

4. CD2AP is an sporadic-Alzheimer's-disease risk gene in a southern Chinese Han population.

5. data suggest that CD2AP acts as a negative regulator of ICAM-1 clustering, which limits the formation of ICAM-1 adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.

6. CD2AP expression in renal tubules may histologically associate with tissue hypoxia and reflected recovery from CsA-mediated renal injury in nephrotic syndrome patients.

7. data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively.

8. Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.

9. Study found a novel association of CD2AP with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS associated with homocysteine

10. CD2AP rs9349407 polymorphism contributes to Alzheimer's disease susceptibility.

11. discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3

12. we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 protein family are able to directly bind the p53 protein, and to discriminate between the two polymorphic variants P72R

13. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro

14. CD2AP gene variants may contribute to susceptibility to end-stage renal disease in patients with type 1 diabetes.

15. FSGS3/CD2AP has a role of barbed-end capping in junctional actin dynamics.

16. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings

17. E2F1 up-regulates the human CD2AP promoter.

18. CD2AP is highly expressed in human plasmacytoid dendritic cells (DC) and positively regulates blood DC antigen 2 (BDCA2)/Fc fragment of IgE high affinity I receptor (FcepsilonR1gamma) signaling.

19. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease

20. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.

Cow (Bovine) CD2-Associated Protein (Cd2ap) Interaktionspartner

1. The authors identified a CLASP1/CD2AP/EB1-containing protein complex that surrounds the Theileria annulata schizont throughout the host cell cycle. This complex also includes the schizont membrane protein Ta-p104 together with a novel secreted Theileria annulata protein (encoded by TA20980), which they term microtubule and SH3 domain-interacting protein (TaMISHIP).

Mouse (Murine) CD2-Associated Protein (Cd2ap) Interaktionspartner

1. Study identified a homozygous frameshift mutation in CD2AP (p.S198fs) in three siblings born of consanguineous parents who developed childhood-onset focal segmental glomerulosclerosis (FSGS) and end stage renal disease. When the same mutation was introduced in mice by gene editing, the mice developed FSGS and kidney failure. These results provide conclusive evidence that homozygous mutation of CD2AP causes FSGS in humans.

2. The data suggest that inhibition of the catalytic activity of SHIP2 is beneficial in reducing oxidative stress, but leads to deleterious increase in apoptosis in podocytes with reduced expression of CD2AP.

3. CD2AP is indicated as a protein up-regulated by HCV infection, which, in turn, stimulates HCV propagation and steatosis by disrupting insulin signaling; targeting CD2AP may offer an opportunity for alleviating HCV infection and its associated liver pathology

4. We used the HIM technology to investigate at nanometer scale resolution the ultrastructural alterations of the glomerular filtration apparatus in mice lacking the critical slit diaphragm-associated protein CD2AP, highlighting the great potential of HIM to provide new insights into the biology and (patho)physiology of glomerular diseases.

5. Ang II induces the relocalization and reduction of CD2AP via AT1R, which would cause podocyte apoptosis by the suppression of CD2AP/PI3-K signaling

6. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

7. Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta in neurons increasing the risk for late-onset AD.

8. CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process.

9. CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting

10. CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk.

11. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro

12. only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51

13. CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation.

14. CD2AP deficiency results in the excretion of intact albumin in knockout mice.

15. the formation of lamellipodia is mediated by a complex of cortactin, CD2AP, and actin capping protein

16. These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria.

17. Sh3kbp1 is SUMOylated by SUMO-1, -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap.

18. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease

19. Coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L).

20. CD2AP is expressed in glomerular podocytes, and may play a role in a specialized adhesion complex known as the slit diaphragm.