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The expression of tetraspanins NET-6 and CD151 may indicate an alteration of their biological function during neoplastic transformation.
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an involvement of CD151 in regulation of ErbB2/ErbB3 heterodimerization and its impact on cell response to Herceptin, is reported.
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CD151 supports anti-cancer drug resistance independent of integrins.
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CD151 promotes proliferation and migration of SK-NEP-1 cells through the GSK-3beta/P21/cyclinD signaling pathway in this study
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Results provide evidence that bi-allelic loss-of-function mutations in CD151 underlie an autosomal recessive mechano-bullous disease with systemic features suggesting that CD151 as the 20th causative, EB-associated gene.
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The expression levels of RNASEH2A, CDK1, and CD151 and their combination could predict the survival of renal cell carcinoma patients.
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We conclude that LAMC1 mRNA acts as a trans regulator to stimulate CD151 expression by competing for miR-124 binding in hepatocellular carcinoma cells.
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CD151 overexpression was associated with poor survival in human solid tumors. CD151 could be a valuable prognosis biomarker or a potential therapeutic target of solid tumors.
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Levels of CD151 Gene Expression are Independently Associated with Survival in Chemoradiotherapy-Naive Patients
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CD151 induces osteosarcoma metastasis likely by regulating cell function through adhesion signaling
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These results elucidated that PIK3C2A mRNA acts as a miR-124 decoy to regulate CD151 and to affect hepatocellular carcinoma malignant phenotypes.
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the tetraspanin CD151 contributes to survival of a subset of high-grade serous ovarian cancer cell lines.
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CD151 in humans thus marks and enables hyperproliferative T cells.
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Here, we demonstrate for the first time that the tetraspanin CD151 supports lymphocyte adhesion to liver endothelium. We show that CD151 is upregulated in chronic liver disease and hepatocellular carcinoma (HCC) and is regulated on endothelium by tissue remodeling and procarcinogenic factors.
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Our data uncover a previously unknown mechanism for modulating human airway smooth muscle contraction, implicating CD151 as a determinant of airway hyper-responsiveness in vivo, likely through regulation of G protein-coupled receptor-induced calcium mobilization and protein kinase c signaling
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Reciprocal fusion gene involving TSPAN4-CD151 is associated with infratentorial anaplastic ependymoma.
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High CD151 expression is associated with hepatocellular carcinoma.
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Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix respectively. The other markers showed no statistical significance(CD151,ALP). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues.
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The findings suggest that, in contrast with previous models, the ligand-binding site of integrin alphaVbeta3, binds to the constant region (helices A and B) of the EC2 domain of CD9, CD81, and CD151 antigens.
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High CD151 expression is associated with Human Cytomegalovirus Infection.