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Binds high-mannose carbohydrates in a Ca(2+)-dependent manner.
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Dectin-2 is a primary factor in activation of NLRP3 (zeige NLRP3 ELISA Kits) inflammasome during Histoplasma capsulatum infection.
this report relates the potential of the Dectin-2/Card9 (zeige CARD9 ELISA Kits)-coupled pathway in ocular autoimmunity. Not only does it contribute to understanding of how innate immune receptors orchestrate T cell-mediated autoimmunity, it also reveals a previously unappreciated ability of fungal-derived signals to promote autoimmunity.
a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells
Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.
activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk (zeige SYK ELISA Kits)-dependent manner.
this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance
these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (zeige TLR4 ELISA Kits) responses through interaction with Dectin-2.
Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 (zeige HAND1 ELISA Kits) differentiation.
this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis
The results indicate differential roles for Dectin-2 and Mincle (zeige CLEC4E ELISA Kits) in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.
Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin (zeige MBL2 ELISA Kits) domain containing 6A)
This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis.
human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2
our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.
The Dectin-2 possess a single extracellular conserved C-type lectin (zeige MBL2 ELISA Kits)-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.
Thus, dectin-1 (zeige CLEC7A ELISA Kits) and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel (zeige NFkBP65 ELISA Kits).
human DECTIN-2 has a role in innate immunity
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
C-type lectin domain family 6, member A
, C-type lectin domain family 6 member A
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10
, C-type lectin superfamily member 10
, DC-associated C-type lectin 2
, dendritic cell-associated C-type lectin 2
, natural killer complex lectin
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
, dectin 2