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BCAT2 encodes a branched chain aminotransferase found in mitochondria.
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The mitochondrial isoform human brain BCAT 2 is largely confined to vascular endothelial cells, whereas the cytosolic human brain BCAT 1 (zeige BCAT1 Antikörper) is restricted to neurons.
BCATc (zeige BCAT1 Antikörper) (cytosolic) has an overall redox potential that is 30 mV lower than BCATm (mitochondrial). Furthermore, the CXXC motif of BCATc (zeige BCAT1 Antikörper) was estimated to be 80 mV lower, suggesting that BCATm is more oxidizing in nature.
leucine supplementation increased the expression of enzymes (BCAT1 (zeige BCAT1 Antikörper), BCAT2 and BCKDK (zeige BCKDK Antikörper)) that metabolize branched-chain amino acids.
Increased blood branched-chain amino acids is sufficient to ameliorate the catabolic effect of LPS (zeige TLR4 Antikörper) on skeletal muscle protein synthesis; this may provide a survival advantage in response to bacterial infection.
BCAT2 has a role in branched chain amino acid (BCAA) metabolism modified by GLUT4 glucose-transporter
This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene.
branched-chain-amino-acid aminotransferase, mitochondrial
, branched chain aminotransferase 2, mitochondrial
, mitochondrial branched-chain aminotransferase 2
, branched chain amino-acid transaminase 2, mitochondrial
, branched chain aminotransferase 1, cytosolic
, hypothetical protein
, branched-chain-amino-acid aminotransferase, mitochondrial-like
, heart branched chain aminotransferase precursor encoding mitochondrial protein
, placental protein 18