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The protein encoded by BIRC7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain.
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Human Monoclonal BIRC7 Primary Antibody für ICC, IF - ABIN252506
Nachmias, Ashhab, Bucholtz, Drize, Kadouri, Lotem, Peretz, Mandelboim, Ben-Yehuda: Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma. in Cancer research 2003
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Human Polyclonal BIRC7 Primary Antibody für IHC (p), IP - ABIN252145
Liu, Kong, Zeng, Liu, Bi, Jiang, Han: Livin may serve as a marker for prognosis of bladder cancer relapse and a target of bladder cancer treatment. in Urologic oncology 2009
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Human Monoclonal BIRC7 Primary Antibody für WB - ABIN2668574
Jiang, Zhou, Yuen, Corless, Heinrich, Fletcher, Demetri, Widlund, Fisher, Hodi: Imatinib targeting of KIT-mutant oncoprotein in melanoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
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Human Polyclonal BIRC7 Primary Antibody für ELISA, WB - ABIN268739
Schatton, Schütte, Frank, Zhan, Hoerning, Robles, Zhou, Hodi, Spagnoli, Murphy, Frank: Modulation of T-cell activation by malignant melanoma initiating cells. in Cancer research 2010
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Human Polyclonal BIRC7 Primary Antibody für ELISA, WB - ABIN2475343
Vucic, Deshayes, Ackerly, Pisabarro, Kadkhodayan, Fairbrother, Dixit: SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). in The Journal of biological chemistry 2002
Human Polyclonal BIRC7 Primary Antibody für IF (p), IHC (p) - ABIN672561
Zhang, Peng, Luo, Zhou: Prospective experimental studies on the renal protective effect of ulinastatin after paraquat poisoning. in World journal of emergency medicine 2014
our results suggest that siRNA-mediated Livin knockdown enhanced the chemosensitivity of the three head and neck squamous cell carcinoma cell lines to cisplatin, 5-FU and docetaxel.
Livin is specifically over-expressed in adrenocortical carcinoma.
Further experiments confirmed the induction of cell apoptosis and suppression of cell proliferation by anti-MM scFv-tP in LiBr cells, along with efficient silence of Livin gene both in vitro and in vivo. Altogether, our findings provide a feasible approach to transport Livin small interfering RNA to malignant melanoma cells which would be a new therapeutic strategy for combating malignant melanoma
MicroRNA-214 inhibits the osteogenic differentiation of human osteoblasts through the direct regulation of BIRC7.
the results of the present study suggested that Livin may enhance tumorigenesis by modulating the mitogenactivated/Akt (zeige AKT1 Antikörper) signaling pathways in human HSCC.
Positive BIRC7 expression and negative KLF4 (zeige KLF4 Antikörper) expression are associated with the progression of PDAC and poor prognosis in patients with PDAC.
High expression of BIRC7 is associated with drug resistance in Renal cell carcinoma (zeige MOK Antikörper).
Data show that cylindromatosis (CYLD (zeige CYLD Antikörper)) overexpression and livin knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (zeige BLNK Antikörper)) cells.
The apoptosisinducing effects of livin and surivin knockdown were investigated using a Hoechst staining kit.
Expression of livin, survivin (zeige BIRC5 Antikörper) and caspase-3 (zeige CASP3 Antikörper) are closely related to the occurrence and development of prostatic cancer.
Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF (zeige VEGFA Antikörper) and MMP-2 (zeige MMP2 Antikörper)/-9. Its silencing resulted in the prevention of xenograft tumor formation.
Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously.
ML-IAP is dispensable for both normal mouse development and ocular homoeostasis.
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
RING finger protein 50
, baculoviral IAP repeat-containing protein 7
, kidney inhibitor of apoptosis protein
, livin inhibitor of apoptosis
, melanoma inhibitor of apoptosis protein
, baculoviral IAP repeat-containing 7
, E3 ubiquitin-protein ligase EIAP
, Embryonic/Egg IAP
, baculoviral IAP repeat-containing 7 (livin)
, E3 ubiquitin-protein ligase EIAP-A
, IAP-like protein
, XIAP homolog XLX
, baculoviral IAP repeat-containing 7 a
, baculoviral IAP repeat-containing protein 7 a
, baculoviral IAP repeat-containing protein 7-A
, embryonic/Egg IAP
, inhibitor of apoptosis-like protein