BPI Fold Containing Family A, Member 1 Proteine (BPIFA1)

Human BPI Fold Containing Family A, Member 1 (BPIFA1) Interaktionspartner

1. SPLUNC1 has antimicrobial and antibiofilm activities against the Burkholderia cepacia complex.

2. Data show that the palate, lung, and nasal epithelium clone (PLUNC) protein level was highly expressed in nontumor nasopharyngeal epithelium than that in nasopharyngeal carcinoma (NPC (zeige NPC1 Proteine)) tissues.

3. These studies identify the role of SPLUNC1 in sinonasal innate immunity and the pathogenesis of CRS (zeige CARS Proteine). Defective expression of SPLUNC1 in CRSwNP patients may lead to insufficient maintenance of the epithelial barrier function

4. High serum SPLUNC1 levels are associated with Pleural Effusion from Lung Cancer Compared to Tuberculosis.

5. PLUNC is a protein of the tear film and suggest that it plays a role in fluid balance and surface tension regulation at the ocular surface.

6. SPLUNC1 can weaken the inflammatory response induced by EBV infection in NPC (zeige NPC1 Proteine) cells through the regulation of the TLR9 (zeige TLR9 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling pathway and control of the tumor inflammatory microenvironment

7. The G allele of rs1078761 may be detrimental to lung function in cystic fibrosis (zeige S100A8 Proteine) owing to decreased levels of BPIFA1 and BPIFB1 (zeige BPIFB1 Proteine).

8. LUNX silencing disrupted primary tumor growth, local invasion, and metastatic colonization

9. pleural fluid LUNX mRNA provided a valuable adjunct in distinguishing malignant pleural effusion caused by lung cancer from benign pleural effusion

10. The observations suggest that, in response to agents or chemical factors, nasal mucosal epithelium will react and produce PLUNC proteins

Pig (Porcine) BPI Fold Containing Family A, Member 1 (BPIFA1) Interaktionspartner

Mouse (Murine) BPI Fold Containing Family A, Member 1 (BPIFA1) Interaktionspartner

1. this study shows that BPIFA1/SPLUNC1 restricts influenza A virus infection

2. SPLUNC1-knockout mice was established in a LPS (zeige TLR4 Proteine)-induced acute lung injury (ALI) mouse model to study the anti-inflammatory effect of SPLUNC1. Results found that SPLUNC1 deficiency upregulated levels of ALI-related cytokines leading to more severe lung injury after LPS (zeige TLR4 Proteine) injection. Moreover, further data discovered that the presence of SPLUNC1 can suppress the recruitment of CD11b (zeige ITGAM Proteine)+Gr-1 (zeige GSR Proteine)+ MDSCs to the spleen in LPS (zeige TLR4 Proteine)-induced ALI.

3. Loss of Splunc1 predisposes mice to the development of otitis media.

4. SPLUNC1 is a crucial component of mucosal innate immune defense against pulmonary infection.

5. SPLUNC1 is present at high concentrations in murine airways under basal conditions, whereas it is suppressed by low-level environmental pathogen-associated molecular patterns and inflammatory signals.

6. SPLUNC1 KO mice demonstrated significantly higher numbers of eosinophils in the lung after OVA challenges than did wild-type mice.

7. Our findings demonstrate a critical in vivo role of SPLUNC1 in host defense against bacterial infection

8. Our data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1 production.

9. splunc5, splunc1, and lplunc1 (zeige BPIFB1 Proteine) are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia

10. SPLUNC1 protein decreases Mycoplasma pneumoniae (Mp) levels and inhibits epithelial IL-8 (zeige IL8 Proteine) production induced by Mp-derived lipoproteins.