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The protein encoded by AIP is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. Zusätzlich bieten wir Ihnen AIP Antikörper (102) und AIP Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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This study of human fibroblasts bearing endogenous heterozygous AIP mutations and transfected pituitary GH3 cells shows that AIP mutations affect the AIP protein level and alter AhR (zeige AHR Proteine) transcriptional activity in a gene- and tissue-dependent manner.
The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4-AIP interaction by AIP mutants may play a role in pituitary tumorigenesis.
The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases.
the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity.
The c.805_825dup allele in AIP, originating from a common ancestor, associates with a severe clinical phenotype of gigantism.
The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts.
Case Report: truncating AIP mutation, p.W279*, in father/daughter presenting with familial isolated pituitary adenoma.
A modest relationship was found between PPARalpha (zeige PPARA Proteine) and AIP expression, both being significantly higher in the presence of pre-operative somatostatin (zeige SST Proteine) analogues in somatotropinoma patients.
The prevalence of AIP(mut (zeige MUT Proteine)) in Turkish patients was found to be 1 % in sporadic acromegaly in the present study.
No digenism with AIP was identified among patients with sporadic pituitary adenomas.
Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone (zeige GH1 Proteine) probably through increased Stat3 (zeige STAT3 Proteine) activation.
Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis.
XAP2 exerts a negative effect on ERalpha (zeige ESR1 Proteine) transcriptional activity and may thus prevent ERalpha (zeige ESR1 Proteine)-dependent events.
Developmental control of apoptosis by the immunophilin (zeige FKBP1A Proteine) aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin (zeige BIRC5 Proteine) protein
Mice with inactivation of aryl hydrocarbon receptor-interacting protein display complete penetrance of pituitary adenomas with aberrant ARNT (zeige ARNT Proteine) expression.
Data show that AIP is not required for the induction of the Cyp1a1 (zeige CYP1A1 Proteine) and Cyp1a2 (zeige CYP1A1 Proteine) genes.
XAP2 hinders importin beta (zeige KPNB1 Proteine) binding to the mAhR complex and represses the transactivation potential of the AhR (zeige AHR Proteine) by stabilizing the receptor complex and/or blocking nucleocytoplasmic shuttling of the AhR (zeige AHR Proteine) complex
PPARalpha (zeige PPARA Proteine) is in a complex with hsp90 (zeige HSP90 Proteine) and XAP2, and XAP2 appears to function as a repressor
XAP2 has a role in stabilization of the dioxin receptor (zeige AHR Proteine)
The role of Xap2 and C-terminal hsp-70 (zeige HSP70 Proteine) interacting protein on the endogenous Ah receptors expressed in mouse cell lines was determined.
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.
aryl hydrocarbon receptor interacting protein
, AH receptor-interacting protein-like
, AH receptor-interacting protein
, HBV X-associated protein 2
, immunophilin homolog ARA9
, aryl-hydrocarbon receptor-interacting protein
, HBV-X associated protein
, immunophilin XAP2