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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (zeige AGTR1 ELISA Kits), plays a protective role against the development of systemic insulin (zeige INS ELISA Kits) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein RdgBbeta (zeige PITPNC1 ELISA Kits) binds 14-3-3 (zeige YWHAQ ELISA Kits) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (zeige CSF2 ELISA Kits) angiotensin II, ACE (zeige ACE ELISA Kits), and ACE2 (zeige ACE2 ELISA Kits) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (zeige AQP4 ELISA Kits) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (zeige AGTR1 ELISA Kits)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (zeige EPHA3 ELISA Kits)-293 cells
CAML (zeige CAMLG ELISA Kits) is an important signal transducer for the actions of Ang II (zeige AGT ELISA Kits) in regulating the calcineurin-NFAT (zeige NFATC1 ELISA Kits) pathway and the interaction of CAML (zeige CAMLG ELISA Kits) with ATRAP may mediate the Ang II (zeige AGT ELISA Kits) actions in vascular physiology
verexpression of ATRAP induced adiponectin expression both in adipose tissue and primary adipocyte. Our data revealed that adipose ATRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose ATRAP.
ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1 (zeige SIRT1 ELISA Kits)-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span.
Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin (zeige INS ELISA Kits) resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling.
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein (zeige TGFB1 ELISA Kits) of the cardiac Ca(2+)-ATPase SERCA2a (zeige CA-P60A ELISA Kits). Suggest that Atrap enhances the activity of SERCA2a (zeige ATP2A2 ELISA Kits) and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (zeige AGT ELISA Kits).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I