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adrenergic receptor showing high affinity for the antagonist WB4101 and agonists phenylephrine and methoxamine.
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Our results suggest that stimulation of alpha1-ARs (zeige SLURP1 ELISA Kits) results in a favorable metabolic profile of increased glucose tolerance, cardiac glucose uptake, leptin (zeige LEP ELISA Kits) secretion and increased whole body lipid metabolism that may contribute to its previously recognized cardioprotective and neuroprotective benefits.
Erythropoietin (zeige EPO ELISA Kits) seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2 (zeige ADRBK1 ELISA Kits)-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.
in mouse ureters: the mRNA for the alpha1A-adrenoceptor was more prevalent than those for the alpha1B- and alpha1D-adrenoceptors
The right ventricle inotropic response to alpha(1)-adrenergic receptors is switched from negative to positive in heart failure, through a pathway involving increased myofilament Ca(2 (zeige CA2 ELISA Kits)+) sensitivity.
mouse hearts lacking alpha(1A)- and alpha(1B (zeige CACNA1B ELISA Kits))-adrenergic receptors retain functional alpha(1)-adrenergic receptor responses involving decreases of coronary flow and ventricular pressure that reflect alpha(1D)-adrenergic receptor-mediated vasoconstriction
alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction
Couplings of 5-HT2B (zeige HTR2B ELISA Kits) and adrenergic alpha1D autoreceptors to reactive oxygen species and TNF-alpha (zeige TNF ELISA Kits) signaling control neurotransmitter metabolism in 1C11-derived neuronal cells.
These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas (zeige AVP ELISA Kits) deferens and consequent sperm ejaculation as well as having a function in fertility
Norepinephrine acts through both alpha1- and beta-adrenergic receptors located on the soma/dendrites of GnRH neurons to directly suppress their excitability throughout the estrous cycle and after ovariectomy.
Hetero-oligomerization of a1B (zeige A1BG ELISA Kits)/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4 (zeige CXCR4 ELISA Kits):atypical chemokine receptor 3 heteromeric complex is required for a1B (zeige A1BG ELISA Kits)/Dadrenergic receptor function.
expression of carboxyl terminus-truncated alpha1D-adrenoceptors alters ERK (zeige EPHB2 ELISA Kits) and p38 (zeige CRK ELISA Kits) phosphorylation state.
alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1 (zeige TGFB1 ELISA Kits), IGF-1 (zeige IGF1 ELISA Kits), hyaluronan and PIP (zeige PIP ELISA Kits) production in human skin fibroblasts.
Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.
Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene.
Data show thah activation of alpha(1)A- or alpha(1)B-adrenergic receptors inhibits serum-promoted cell proliferation, whereas alpha(1)D-AR activation does not show such an inhibitory effect.
These studies suggest that gC1qR (zeige C1QBP ELISA Kits) interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs (zeige SLURP1 ELISA Kits), and this interaction depends on the presence of an intact C-tail.
Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs (zeige SLURP1 ELISA Kits) were prevalent over alpha1B ARs (zeige SLURP1 ELISA Kits).
Differential methylation of proximal GC boxes in the ADRA1D promoter disrupts Sp1 (zeige PSG1 ELISA Kits) binding in a cell-specific manner resulting in repression of basal alpha1dAR expression.
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.
alpha-1A adrenergic receptor
, alpha-1D adrenergic receptor
, alpha-1D adrenoceptor
, alpha-1D adrenoreceptor
, adrenergic receptor delta1
, adrenergic receptor, alpha 1d
, adrenergic, alpha-1D-, receptor
, alpha 1D-adrenoceptor
, alpha 1D-adrenoreceptor
, adrenergic, alpha -1D-, receptor
, adrenergic, alpha-1A-, receptor
, alpha-1D-adrenergic receptor
, alpha-adrenergic receptor 1a
, alpha 1d adrenoceptor