anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Antikörper

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

1. The results reveal the potential regulatory mechanism of FTH1P3 on breast cancer paclitaxel resistance through miR-206/ABCB1 axis.

2. Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells.

3. High MDR1 expression is associated with acute lymphoblastic leukemia.

4. The study demonstrated that the simultaneous presence of TMDR1, A CYP2D6*4 and A NAT2*7 alleles robustly increased the risk of developing ulcerative colitis by 3.49-fold. The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.

5. HIF1A-induced MDR1 and MRP4 promote Th17 responses in Crohn's disease.

6. In conclusion, we provide evidence that P-gp may be involved in an AhR-dependent detoxification process induced in response to the uremic toxin IS.

7. sofosbuvir GS-331007 metabolite plasma levels were affected by variants in the ABCB1 and HNFalpha genes

8. The contribution of polymorphisms in ABCB1 to drug pharmacokinetics.

9. FENDRR attenuates NSCLC cell stemness through inhibiting the HuR/MDR1 axis

10. Significant associations between SNPs in MDR1 and outcome of multiple myeloma (MM) were found in 110 MM patients that underwent bortezomib-based treatment.

11. WBP2 directly promoted P-glycoprotein expression through binding to ERalpha to increase the doxorubicin resistance of ERalpha-positive MCF-7 cells.

12. this study shows that high MDR-1 expression by mucosal-associated invariant T cells confers resistance to cytotoxic but not immunosuppressive MDR-1 substrates

13. A correlation exists between the ABCB1 C3435T gene polymorphism and post-stroke depression in the Han population in South Anhui province, China.

14. elevated levels of ABCB1 gene expression are associated with response to metformin with chemotherapy in acute lymphoblastic leukemia

15. There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype.

16. WYE354 stimulated the ATPase activity of ABCB1, which was consistent with in silico predictions using a human ABCB1 mouse homology model, indicating that WYE354 is a potent substrate of ABCB1.

17. ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.

18. this study determined the 3.5-angstrom cryo-electron microscopy structure of substrate-bound human ABCB1 reconstituted in lipidic nanodiscs, revealing a single molecule of the chemotherapeutic compound paclitaxel (Taxol) bound in a central, occluded pocket.

19. CCL20 enhanced doxorubicin resistance of OC cells by regulating ABCB1 expression

20. MDR1 (rs1045642) and CYP46A1 (rs754203) genes polymorphism was not found associated with Fasting Blood Sugar (FBS), Diastolic Blood Pressure (DBP) or Systolic Blood Pressure (SBP).

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

1. P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

1. ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.

2. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

3. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

4. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

5. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

6. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

7. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

8. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

9. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

10. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

11. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

12. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

13. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

14. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

15. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

16. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

17. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

18. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

19. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

20. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.