ATP Citrate Lyase (ACLY) ELISA Kits

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Zusätzlich bieten wir Ihnen ACLY Antikörper (122) und ACLY Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
ACLY 24159 P16638
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 11.75 pg/mL 47-3000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Ratte 0.625-40 ng/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
0.312-20 ng/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für ACLY Interaktionspartner

Human ATP Citrate Lyase (ACLY) Interaktionspartner

  1. ACLY facilitates histone acetylation at double-strand break (DSB) sites, impairing 53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination. ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.

  2. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen.

  3. CUL3 (zeige CUL3 ELISA Kits) interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

  4. we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.

  5. Results show that ACLY is a key phosphoprotein effector of IL-2 (zeige IL2 ELISA Kits)-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2 (zeige IL2 ELISA Kits)-driven activation of AKT (zeige AKT1 ELISA Kits), and depletion or inactivation of ACLY compromises IL-2 (zeige IL2 ELISA Kits)-promoted T-cell growth.

  6. ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2 (zeige PLIN2 ELISA Kits)), a marker of lipid droplet formation, associated with favorable prognosis

  7. ACC1 (zeige ACACA ELISA Kits) and ACLY regulate the levels of ETV4 (zeige ETV4 ELISA Kits) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (zeige ACACA ELISA Kits)/ACLY-alpha-ketoglutarate-ETV4 (zeige ETV4 ELISA Kits) axis is a novel means by which metabolic states regulate transcriptional output

  8. ACL activity is associated with increased ATP. Activation of this IGF1 (zeige IGF1 ELISA Kits)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  9. These results suggest that the combined expression of GLUT1 (zeige SLC2A1 ELISA Kits) and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  10. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

Mouse (Murine) ATP Citrate Lyase (ACLY) Interaktionspartner

  1. these data indicate that engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency.

  2. ACL (zeige APOC4 ELISA Kits) plays a critical role in epigenetic regulation of diabetic renal fibrosis.

  3. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr (zeige LDLR ELISA Kits) knockout mouse model of metabolic dysregulation.

  4. IL-4 (zeige IL4 ELISA Kits) signaling co-opts the Akt (zeige AKT1 ELISA Kits)-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA (zeige LPCAT1 ELISA Kits) synthesis, leading to increased histone acetylation and macrophage gene induction.

  5. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (zeige TLR4 ELISA Kits) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  6. Results suggest a role for DNA methyltransferase 1 (DNMT1 (zeige DNMT1 ELISA Kits)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (zeige MLXIP ELISA Kits)-148a-dependent mechanism for regulating DNMT1 (zeige DNMT1 ELISA Kits) during adipogenesis.

  7. Differences between human and rodent pancreatic islets: low pyruvate carboxylase (zeige PC ELISA Kits), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  8. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (zeige APOC4 ELISA Kits) in lipid metabolism.

  9. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  10. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

Pig (Porcine) ATP Citrate Lyase (ACLY) Interaktionspartner

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (zeige TFAP2A ELISA Kits).

Cow (Bovine) ATP Citrate Lyase (ACLY) Interaktionspartner

  1. we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China

ACLY Antigen-Profil

Beschreibung des Gens

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit ATP Citrate Lyase (ACLY) ELISA Kits

  • ATP citrate lyase (ACLY) Antikörper
  • ATP citrate lyase S homeolog (acly.S) Antikörper
  • ATP-citrate synthase (LOC587157) Antikörper
  • ATP citrate lyase (acly) Antikörper
  • ATP citrate lyase (ATPCL) Antikörper
  • ATP-citrate synthase (LOC5564509) Antikörper
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291) Antikörper
  • ATP-citrate synthase (Bm1_26245) Antikörper
  • atp-citrate synthase (ACL) Antikörper
  • ATP citrate lyase (Acly) Antikörper
  • ATP citrate lyase a (aclya) Antikörper
  • A730098H14Rik Antikörper
  • ACL Antikörper
  • acly Antikörper
  • anon-WO0140519.179 Antikörper
  • ATPCL Antikörper
  • AW538652 Antikörper
  • BcDNA:LD21334 Antikörper
  • cb722 Antikörper
  • CG8322 Antikörper
  • Clatp Antikörper
  • dATPCL Antikörper
  • DDBDRAFT_0205389 Antikörper
  • DDBDRAFT_0235360 Antikörper
  • DDB_0205389 Antikörper
  • DDB_0235360 Antikörper
  • DmATPCL Antikörper
  • Dmel\\CG8322 Antikörper
  • l(2)01466 Antikörper
  • l(2)k09217 Antikörper
  • n(2)k09217 Antikörper
  • zgc:92008 Antikörper

Bezeichner auf Proteinebene für ATP Citrate Lyase (ACLY) ELISA Kits

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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