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ADAMTS8 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.
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This study demonstrated that Cortical fast-spiking parvalbumin (zeige PVALB ELISA Kits) interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.
ADAMTS-4 (zeige ADAMTS4 ELISA Kits) expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
This study showed that ADAMTS1 (zeige ADAMTS1 ELISA Kits), 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)
ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer.
Study uncovers the tumor suppressive function of ADAMTS8 and its frequent methylation in certain tumors could be developed as a potential biomarker.
ADAMTS 8, CCL23 (zeige CCL23 ELISA Kits), and TNFSF15 (zeige TNFSF15 ELISA Kits) are implicated in anti-angiogenic activities
Ability of ADAMTS-8 to cleave aggrecan (zeige ACAN ELISA Kits) at aggrecanase (zeige ADAMTS4 ELISA Kits)-susceptible Glu373-Ala374 peptide bond. Presence of ADAMTS-8 mRNA transcripts in normal and osteoarthritic human cartilage. (ADAMTS-8)
Downdownregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease.
ADAMTS8 and ADAMTS15 (zeige ADAMTS15 ELISA Kits) have emerged as novel predictors of survival in patients with breast carcinoma
Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% brain tumours. A role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis.
ADAMTS-4 (zeige ADAMTS4 ELISA Kits) and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
ADAM metallopeptidase with thrombospondin type 1 motif, 8
, A disintegrin and metalloproteinase with thrombospondin motifs 8
, ADAM-TS 8
, ADAMTS-8 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2)
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8