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ADAMTS6 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.
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Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 inhibits and ADAMTS10 (zeige ADAMTS10 ELISA Kits) is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition.
ADAMTS6 inhibits breast tumor development by regulating the ERK (zeige EPHB2 ELISA Kits) pathway via binding of miR (zeige MLXIP ELISA Kits)-221-3p
Novel inguinal hernia susceptibility genes are identified as EFEMP1 (zeige FBLN3 ELISA Kits), WT1 (zeige WT1 ELISA Kits), EBF2 and ADAMTS6.
Study shows that the ADAMTS6 transcript contains unusually large untranslated regions (UTRs) at both the 5' and 3'end, and the 5'UTR (zeige UTS2R ELISA Kits) contains 11 AUG codons upstream of the predicted ADAMTS6 start codon.
The gain of function studies indicated that ADAM metallopeptidase with thrombospondin type 1 motif 6 activate NR5A1 (zeige NR5A1 ELISA Kits) gene expression.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
A disintegrin and metalloproteinase with thrombospondin motifs 6
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6