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ADAMTS14 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Zusätzlich bieten wir Ihnen ADAMTS14 Kits (13) und und viele weitere Produktgruppen zu diesem Protein an.
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These results suggest an involvement of ADAMTS14 single-nucleotide polymorphisms rs12774070 and rs61573157 in the liver tumorigenesis and implicate the ADAMTS14 gene polymorphism as a predict factor during the progression of hepatocellular carcinoma.
ADAMTS14 SNPs and environmental mutagens are a risk factor of oral tumorigenesis.
Suggest the existence of an epigenetic field defect for cancerization disrupting the methylation patterns of several loci, including MGMT or ADAMTS14, that may lead to predictive biomarkers for colorectal cancer in African Americans.
Data indicate that ADAMTS2, 3 and 14 cleave the amino-propeptide of fibrillar collagens. [review]
No significant associations were observed in males. In conclusion, the nsSNP rs4747096 in ADAMTS14 was associated with knee OA in female Thai patients; therefore, the role of ADAMTS14 in OA seems to be gender-dependent.
Carriage of the ADAMTS14 rs4747096 GG variant appears to delay onset of the injury in Achilles tendon pathology.
ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina.
This study suggest potentially important role for the ADAMTS14 gene in predisposition to MS.
findings implicate ADAMTS14 in osteoarthritis
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined.
A disintegrin and metalloproteinase with thrombospondin motifs 14
, ADAM-TS 14
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
, metalloprotease-disintegrin protease