anti-ADAM Metallopeptidase Domain 19 (Adam19) Antikörper

Mouse (Murine) ADAM Metallopeptidase Domain 19 (Adam19) Interaktionspartner

1. TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19

2. Thus, we found that electrical stimulation accelerated NMJ formation, possibly through activation of ADAM19/neuregulin/ErbB signaling in NG108-15 cells.

3. Meltrin beta-mini is a new isoform that induces neuron outgrowth in neuronal cells

4. evaluation of its catalytic activity; potential role in shedding TRANCE in cells where both molecules are highly expressed, such as in osteoblasts

5. participates in the development of the endocardial cushion

6. Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart.

7. This study identifies a novel sheddase, ADAM17, for Kitl1 and Kitl2, and demonstrates that ADAM19 can reduce ADAM17-dependent phorbol-ester-stimulated Kitl1 ectodomain shedding.

8. meltrin-beta functions as a modulator of juxtacrine signaling from axons that activate the Akt pathway and the Krox-20 expression, which is the prerequisite for Schwann cell differentiation

9. It plays multiple roles in the regulation of signal transduction between neuronal cells. (review)

Human ADAM Metallopeptidase Domain 19 (Adam19) Interaktionspartner

1. 3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease.

2. ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer.

3. these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells

4. miR-30c inhibited colon cancer cells via targeting ADAM19.

5. four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease.

6. ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function.

7. MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19

8. ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls.

9. Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments.

10. Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma.

11. These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2.

12. ADAM19 correlates with the progress and prognosis of endometrial carcinoma.

13. ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation.

14. activation by furin via one of two consecutive recognition sites

15. investigation of proteolytic activity

16. yeast two-hybrid screen performed in fetal brain cDNA library isolated four proteins that interact with the cytoplasmic tail of ADAM19

17. A new autolytic processing site at Lys543-Val544 was identified in soluble mutants of ADAM19 when these cysteine residues were individually mutated to serine residues.

18. ChIP assays demonstrated high levels of acetylated histone H3 in the promoter region of the MADDAM gene in TSA-treated THP-1 cells/dendritic cells compared to macrophages, indicating an important role of histone acetylation in regulating the MADDAM gene.

19. ADAM19 may have a modulatory role in the dysfunctional renal allograft state

20. results suggest that ADAM19 has a constitutive alpha-secretase activity for amyloid precursor protein

Xenopus laevis ADAM Metallopeptidase Domain 19 (Adam19) Interaktionspartner

1. A reduction of ADAM19 protein in gastrula stage embryos results in a decrease of Brachyury expression in the notochord concomitant with an increase in the dorsal markers, Goosecoid and Chordin.