anti-Adenomatous Polyposis Coli (APC) Antikörper

Bezeichnung:
anti-Adenomatous Polyposis Coli Antikörper (APC)
Auf www.antikoerper-online.de finden Sie aktuell 206 Adenomatous Polyposis Coli (APC) Antikörper von 24 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Adenomatous Polyposis Coli Kits (20) und Adenomatous Polyposis Coli Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 245 Adenomatous Polyposis Coli Produkte verfügbar.
Synonyme:
AI047805, APC1, AU020952, AW124434, BTPS2, CC1, DP2, DP2.5, DP3, fap, fpc, GS, mAPC, Min, PPP1R46, RATAPC, xapc

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Am meisten referenzierte anti-Adenomatous Polyposis Coli Antikörper

  1. Human Monoclonal APC Primary Antibody für IF, WB - ABIN393899 : Jaulin, Kreitzer: KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC. in The Journal of cell biology 2010 (PubMed)
    Zeige alle 5 Referenzen für 393899

  2. Human Monoclonal APC Primary Antibody für IHC (fro), IP - ABIN152091 : Abutaily, Collins, Roche: Cadherins, catenins and APC in pleural malignant mesothelioma. in The Journal of pathology 2003 (PubMed)
    Zeige alle 2 Referenzen für 152091

  3. Mouse (Murine) Monoclonal APC Primary Antibody für EIA, IF - ABIN1105399 : Hendriksen, Jansen, Brown, van der Velde, van Ham, Galjart, Offerhaus, Fagotto, Fornerod: Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway. in Journal of cell science 2008 (PubMed)

  4. Human Polyclonal APC Primary Antibody für ICC, IF - ABIN4280975 : Liu, Tackmann, Yang, Zhang: Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis. in Oncogene 2016 (PubMed)

Weitere Antikörper gegen Adenomatous Polyposis Coli Interaktionspartner

Mouse (Murine) Adenomatous Polyposis Coli (APC) Interaktionspartner

  1. In cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 (zeige RAD52 Antikörper) gene suppressed tumor growth and prolonged lifespan.

  2. APC is required by Schwann cells for their timely differentiation to mature, myelinating cells and plays a crucial role in radial axonal sorting and peripheral nervous system myelination.

  3. Msi-1 (zeige MSI1 Antikörper) contributes to intestinal tumorigenesis driven by Apc loss, and validate the pursuit of Msi-1 (zeige MSI1 Antikörper) inhibitors as chemo-prevention agents to reduce tumor burden.

  4. APC haploinsufficiency coupled with p53 (zeige TP53 Antikörper) deletion resulted in the development of a distinct type of pancreatic premalignant precursors, mucinous cystic neoplasms (MCNs)

  5. Gasdermin C is upregulated by inactivation of Tgfbr2 (zeige TGFBR2 Antikörper) in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

  6. By sequencing Apc and Ctnnb1 (zeige CTNNB1 Antikörper) genes, we found that most PhIP (zeige PHIP Antikörper)-induced small intestinal tumors in obese mice carried only a single heterozygous mutation in Apc . Our findings demonstrate that PhIP (zeige PHIP Antikörper)-induced small intestinal carcinogenesis in hCYP1A-db/db (zeige LEPR Antikörper) mice is promoted by obesity and involves Apc mutation and inactivation by DNA hypermethylation

  7. Elevated coexpression of KITENIN (zeige Vangl1 Antikörper) and ErbB4 (zeige ERBB4 Antikörper)-CYT (zeige CYGB Antikörper)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment

  8. The activation of canonical Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling by deletion of Apc in cardiomyocytes led to ventricular hyperplasia.

  9. demonstrated that despite having both Kras and Pik3ca (zeige PIK3CA Antikörper) mutations at the time of tumor initiation from loss of APC

  10. Suggest that the early activation of Hsf1 (zeige HSF1 Antikörper) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.

Human Adenomatous Polyposis Coli (APC) Interaktionspartner

  1. beta-catenin (zeige CTNNB1 Antikörper) reactivity was noted in all familial adenomatous polyposis-associated Gardner fibromas and in 1/4 APC wild-type cases

  2. The rs75612255 C allele and rs113017087 C allele in promoter 1A of APC as well as the rs138386816 T allele and rs115658307 T allele in promoter 1B of APC significantly increased luciferase activity in the human erythromyeloblastoid leukaemia cell line K562.

  3. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium

  4. Finally, we observed that expression of miR-19a significantly correlates with beta-catenin levels in colorectal cancer specimens, and it is associated to the aggressive stage of tumor progression. Thus, our study reveals that miR-17-92 cluster is directly regulated by APC/b-catenin pathway and could be a potential therapeutic target in colon cancers with aberrant APC/b-catenin signaling.

  5. Findings show that colorectal Cancer patients-derived cells with short APC mutants were either sensitive or responsive to tankyrase inhibitors corroborating the idea that APC with complete deletion of seven 20-AA repeats could be a predictive biomarker for the sensitivity to tankyrase inhibitors.

  6. Our study showed that mutations in the APC gene alter the protein expression and cell cycle regulation in diffuse type gastric adenocarcinoma.

  7. Gasdermin C is upregulated by inactivation of Tgfbr2 (zeige TGFBR2 Antikörper) in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

  8. Nine patients with 21- approximately 100 colorectal adenomas (50%) and the two positive controls, showed somatic mosaicism, with identical APC variants in adenomas tested.

  9. These result suggested that miR (zeige MLXIP Antikörper)-590-3p can promote osteogenic differentiation via suppressing APC expression and stabilizing beta-catenin (zeige CTNNB1 Antikörper).

  10. The present findings indicate epigenetic silencing of APC in advanced gallbladder cancer (GBC). The methylation pattern, followed by expression analysis of APC may be suggested for diagnostic, prognostic and therapeutic purposes in GBC in future

Xenopus laevis Adenomatous Polyposis Coli (APC) Interaktionspartner

  1. the Amer2 (zeige AMER2 Antikörper)-EB1 (zeige MAPRE1 Antikörper)-APC complex regulates cell migration by altering microtubule stability.

  2. Data show that importin-beta (zeige KPNB1 Antikörper) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.

  3. APC and Axin (zeige AXIN1 Antikörper) are involved in the Wnt (zeige WNT2 Antikörper) pathway

  4. depletion of APC from cystostatic factor (CSF (zeige CSF2 Antikörper)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (zeige TUBB Antikörper) distribution in spindles and asters formed in such extracts

  5. An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (zeige MAD2L1 Antikörper), an essential mitotic checkpoint (zeige BUB3 Antikörper) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.

Adenomatous Polyposis Coli (APC) Antigen-Profil

Beschreibung des Gens

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Alternative names and synonyms associated with Adenomatous Polyposis Coli (APC)

  • adenomatous polyposis coli (APC) Antikörper
  • adenomatous polyposis coli (apc) Antikörper
  • adenomatous polyposis coli protein (Smp_139190) Antikörper
  • adenomatosis polyposis coli (Apc) Antikörper
  • adenomatous polyposis coli (Apc) Antikörper
  • AI047805 Antikörper
  • APC1 Antikörper
  • AU020952 Antikörper
  • AW124434 Antikörper
  • BTPS2 Antikörper
  • CC1 Antikörper
  • DP2 Antikörper
  • DP2.5 Antikörper
  • DP3 Antikörper
  • fap Antikörper
  • fpc Antikörper
  • GS Antikörper
  • mAPC Antikörper
  • Min Antikörper
  • PPP1R46 Antikörper
  • RATAPC Antikörper
  • xapc Antikörper

Bezeichner auf Proteinebene für APC

adenomatosis polyposis coli , adenomatous polyposis coli protein , multiple intestinal neoplasia , adenomatosis polyposis coli tumor suppressor , deleted in polyposis 2.5 , protein phosphatase 1, regulatory subunit 46 , adenomatous polyposis coli homolog

GENE ID SPEZIES
100064431 Equus caballus
461999 Pan troglodytes
479139 Canis lupus familiaris
779466 Xenopus (Silurana) tropicalis
8350424 Schistosoma mansoni
11789 Mus musculus
324 Homo sapiens
24205 Rattus norvegicus
100517932 Sus scrofa
533233 Bos taurus
399455 Xenopus laevis
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