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We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.
The CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.
IL-7 (zeige IL7 Proteine)/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity.
this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice
results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin (zeige TSLP Proteine) responsiveness and that IL-4 (zeige IL4 Proteine) can upregulate IL-7Ralpha on DCs.
IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver
These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (zeige TSLP Proteine) can replace IL-7 (zeige IL7 Proteine) in providing these signals.
Bcl6 (zeige BCL6 Proteine) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (zeige STAT5A Proteine) axis.
results suggest that LNK (zeige SH2B3 Proteine) suppresses IL-7R/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (zeige SH2B3 Proteine) mutations.
The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin (zeige INS Proteine) resistance in mice.
This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.
Data show the contribution of IL-23/IL-23 (zeige IL23A Proteine) receptor (zeige IL23R Proteine) and IL-7/IL-7 (zeige IL7 Proteine) receptor signaling in Th17 and Th1 (zeige HAND1 Proteine) cell dynamics during experimental autoimmune encephalomyelitis (EAE).
Data demonstrate that IL-7R expression is regulated by HBX via NF-kappaB (zeige NFKB1 Proteine) and Notch1 (zeige NOTCH1 Proteine) pathways to facilitate the activation of intracellular pathways and expression of associated molecules, and contribute to proliferation and migration of hepatoma cells.
We show that heterozygous IL7R exon deletions are common in T-B+NK+ SCID (zeige PRKDC Proteine) and are detectable by WES. They should be considered if Sanger sequencing fails to detect homozygous or compound heterozygous IL7R SNVs or INDELs.
Tuberculosis patients had lower soluble IL-7R and higher IL-7 (zeige IL7 Proteine) plasma concentrations as compared to healthy contacts.
CD56 (zeige NCAM1 Proteine)(bright) NK IL-7Ralpha expression negatively associates with HCV level, and IL-7 (zeige IL7 Proteine)-induced NK function is impaired during HCV and HIV infections
IL-7 (zeige IL7 Proteine) has a role inducing epitope masking of gammac protein in IL-7 (zeige IL7 Proteine) receptor signaling complex
The results of this study showed that IL-17 (zeige IL17A Proteine) receptor (IL-17R) were clearly up regulated in mesial temporal lobe epilepsy at both mRNA and protein levels, compared with control.
the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 (zeige PTPN22 Proteine) c.1858C>T (rs2476601), TLR4 (zeige TLR4 Proteine) c.896A>G (rs4986790) and TLR4 (zeige TLR4 Proteine) c.1196C>T (rs4986791), IL7R c.197T>C (rs1494555) and IL7R c.412G>A (rs1494558).
The interleukin-7 receptor alpha (IL-7Ralpha) signaling pathways are prime therapeutic targets because these pathways harbor genetic aberrations in both T-cell ALL and B-cell precursor ALL. Therapeutic targeting of the IL-7Ralpha signaling pathways may lead to improved outcomes in a subset of patients.
Therefore, generalized CD8 (zeige CD8A Proteine)+ T-cell impairment in HCV infection is characterized, in part, by impaired IL-7 (zeige IL7 Proteine)-mediated signalling and survival, independent of CD127 expression. This impairment is more pronounced in the liver and may be associated with an increased potential for apoptosis. This generalized CD8 (zeige CD8A Proteine)+ T-cell impairment represents an important immune dysfunction in chronic HCV infection that may alter patient health.
Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
interleukin 7 receptor
, interleukin-7 receptor subunit alpha-like
, IL-7 receptor alpha chain
, IL-7 receptor subunit alpha
, IL-7R subunit alpha
, interleukin 7 receptor alpha chain
, interleukin-7 receptor subunit alpha
, CD127 antigen
, interleukin 7 receptor isoform H5-6
, Interleukin-7 receptor subunit alpha-like protein
, Interleukin-7 receptor subunit alpha