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IL7R Proteine (IL7R)

Interleukin 7 Receptor Proteine (IL7R)
Auf finden Sie aktuell 31 Interleukin 7 Receptor (IL7R) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen IL7R Antikörper (387) und IL7R Kits (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 461 IL7R Produkte verfügbar.
CD127, CDW127, IL-7R-alpha, IL-7RA, IL-7Ralpha, IL7R, IL7RA, ILRA
alle Proteine anzeigen Gen GeneID UniProt
IL7R 16197 P16872
IL7R 3575 P16871
IL7R 294797  

Weitere Synonyme anzeigen

IL7R Proteine (IL7R) nach Spezies

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Am meisten referenzierte IL7R Proteine

  1. Human IL7R Protein expressed in Human Cells - ABIN2003675 : Sudo, Nishikawa, Ohno, Akiyama, Tamakoshi, Yoshida, Nishikawa: Expression and function of the interleukin 7 receptor in murine lymphocytes. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Zeige alle 4 Referenzen für ABIN2003675

  2. Mouse (Murine) IL7R Protein expressed in Human Cells - ABIN2007306 : Park, Martin, Garka, Gliniak, Di Santo, Muller, Largaespada, Copeland, Jenkins, Farr, Ziegler, Morrissey, Paxton, Sims: Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. in The Journal of experimental medicine 2000 (PubMed)
    Zeige alle 4 Referenzen für ABIN2007306

  3. Rat (Rattus) IL7R Protein expressed in Human Cells - ABIN2009137 : Pandey, Ozaki, Baumann, Levin, Puel, Farr, Ziegler, Leonard, Lodish: Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. in Nature immunology 2001 (PubMed)
    Zeige alle 4 Referenzen für ABIN2009137

  4. Rat (Rattus) IL7R Protein expressed in Human Cells - ABIN2009136 : Kaech, Tan, Wherry, Konieczny, Surh, Ahmed: Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. in Nature immunology 2003 (PubMed)
    Zeige alle 4 Referenzen für ABIN2009136

  5. Human IL7R Protein expressed in HEK-293 Cells - ABIN2181401 : McElroy, Dohm, Walsh: Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. in Structure (London, England : 1993) 2009 (PubMed)

Weitere Proteine zu IL7R Interaktionspartnern

Rhesus Monkey Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.

  2. The CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.

Mouse (Murine) Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (zeige TSLP Proteine) can replace IL-7 (zeige IL7 Proteine) in providing these signals.

  2. Bcl6 (zeige BCL6 Proteine) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (zeige STAT5A Proteine) axis.

  3. results suggest that LNK (zeige SH2B3 Proteine) suppresses IL-7R/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (zeige SH2B3 Proteine) mutations.

  4. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin (zeige INS Proteine) resistance in mice.

  5. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.

  6. Data show the contribution of IL-23/IL-23 (zeige IL23A Proteine) receptor (zeige IL23R Proteine) and IL-7/IL-7 (zeige IL7 Proteine) receptor signaling in Th17 and Th1 (zeige HAND1 Proteine) cell dynamics during experimental autoimmune encephalomyelitis (EAE).

  7. Inhibition of the IL-7 (zeige IL7 Proteine) receptor inhibits tumor growth in murine models of melanoma.

  8. The combined loss of Gads (zeige GRAP2 Proteine) and CD127 reveals a novel function of Gads (zeige GRAP2 Proteine) prior to T cell receptor beta expression

  9. Results provided evidence that IL-7 (zeige IL7 Proteine)/IL-7R induce VEGF-D (zeige Figf Proteine) upregulation and promote lymphangiogenesis via c-Fos/c-Jun (zeige JUN Proteine) pathway in lung cancer.

  10. data suggest that IL-7Ralpha Tyr (zeige TYR Proteine)(449) was essential for IL-7Ralpha signaling in bone marrow B cell development and survival.

Human Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (zeige TSLP Proteine) can replace IL-7 (zeige IL7 Proteine) in providing these signals.

  2. Study showed that a genetic variant in the 5' UTR of DDX39B (zeige DDX39 Proteine) reduces translation of DDX39B (zeige DDX39 Proteine) mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B (zeige DDX39 Proteine) variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.

  3. study identifies casein kinase 2 as a major player in the effects of interleukin-7 (zeige IL7 Proteine) and interleukin-7 receptor in T-cell acute lymphoblastic leukemia

  4. CD45RA distinguishes CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression.

  5. In summary, our study demonstrates that IL-7 (zeige IL7 Proteine)/IL-7R axis promotes the invasion and migration of prostate cancer cells, through activation of AKT (zeige AKT1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) pathway and upregulation of MMP-3 (zeige MMP3 Proteine) and MMP-7 (zeige MMP7 Proteine) expression

  6. Meta-analysis demonstrated that the IL7R T244I polymorphism was associated with susceptibility to multiple sclerosis

  7. This study suggested that the IL7R C allele was associated with an increased risk of MS and larger-scale studies of populations are needed to explore the roles played by the IL7R T244I polymorphism during the pathogenesis of multiple sclerosis.

  8. the variant of IL-7RA (rs6897932) was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 (zeige IL7 Proteine) (rs1520333) with MS patients.

  9. this study shows that in human CD8 (zeige CD8A Proteine) T cells that IL-7 (zeige IL7 Proteine) binding to its receptor induces CD127 internalization via clathrin-mediated endocytosis, transport of the receptor from early to late endosomes and ultimately degradation of CD127 by the proteasome.

  10. Immunophenotyping with CD135 (zeige FLT3 Proteine) and CD117 predicts the FLT3 (zeige FLT3 Proteine), IL-7R and TLX3 (zeige TLX3 Proteine) gene mutations in childhood T-cell acute leukemia.

Horse (Equine) Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.

IL7R Protein Überblick

Protein Überblick

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).

Alternative names and synonyms associated with IL7R

  • interleukin 7 receptor (IL7R)
  • interleukin 7 receptor (LOC100226205)
  • interleukin 7 receptor (Il7r)
  • CD127 Protein
  • CDW127 Protein
  • IL-7R-alpha Protein
  • IL-7RA Protein
  • IL-7Ralpha Protein
  • IL7R Protein
  • IL7RA Protein
  • ILRA Protein

Bezeichner auf Proteinebene für Interleukin 7 Receptor Proteine (IL7R)

interleukin 7 receptor , interleukin-7 receptor subunit alpha-like , IL-7 receptor alpha chain , IL-7 receptor subunit alpha , IL-7R subunit alpha , IL-7R-alpha , IL-7RA , interleukin 7 receptor alpha chain , interleukin-7 receptor subunit alpha , CD127 antigen , interleukin 7 receptor isoform H5-6 , Interleukin-7 receptor subunit alpha-like protein , Interleukin-7 receptor subunit alpha

699869 Macaca mulatta
100226205 Taeniopygia guttata
100343726 Oryctolagus cuniculus
100461835 Pongo abelii
100583768 Nomascus leucogenys
16197 Mus musculus
3575 Homo sapiens
294797 Rattus norvegicus
100034169 Equus caballus
612582 Canis lupus familiaris
521554 Bos taurus
100397720 Callithrix jacchus
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