IL7R Proteine (IL7R)

Auf finden Sie aktuell 31 Interleukin 7 Receptor (IL7R) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen IL7R Antikörper (398) und IL7R Kits (28) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 473 IL7R Produkte verfügbar.
CD127, CDW127, IL-7R-alpha, IL-7RA, IL-7Ralpha, IL7R, IL7RA, ILRA
alle Proteine anzeigen Gen GeneID UniProt
IL7R 16197 P16872
IL7R 3575 P16871
IL7R 294797  

IL7R Proteine (IL7R) nach Spezies

Weitere Proteine zu IL7R Interaktionspartnern

Rhesus Monkey Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.

  2. The CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.

Mouse (Murine) Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin (zeige TSLP Proteine) responsiveness and that IL-4 (zeige IL4 Proteine) can upregulate IL-7Ralpha on DCs.

  2. IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver

  3. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (zeige TSLP Proteine) can replace IL-7 (zeige IL7 Proteine) in providing these signals.

  4. Bcl6 (zeige BCL6 Proteine) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (zeige STAT5A Proteine) axis.

  5. results suggest that LNK (zeige SH2B3 Proteine) suppresses IL-7R/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (zeige SH2B3 Proteine) mutations.

  6. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin (zeige INS Proteine) resistance in mice.

  7. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.

  8. Data show the contribution of IL-23/IL-23 (zeige IL23A Proteine) receptor (zeige IL23R Proteine) and IL-7/IL-7 (zeige IL7 Proteine) receptor signaling in Th17 and Th1 (zeige HAND1 Proteine) cell dynamics during experimental autoimmune encephalomyelitis (EAE).

  9. Inhibition of the IL-7 (zeige IL7 Proteine) receptor inhibits tumor growth in murine models of melanoma.

  10. The combined loss of Gads (zeige GRAP2 Proteine) and CD127 reveals a novel function of Gads (zeige GRAP2 Proteine) prior to T cell receptor beta expression

Human Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. Tuberculosis patients had lower soluble IL-7R and higher IL-7 (zeige IL7 Proteine) plasma concentrations as compared to healthy contacts.

  2. CD56 (zeige NCAM1 Proteine)(bright) NK IL-7Ralpha expression negatively associates with HCV level, and IL-7 (zeige IL7 Proteine)-induced NK function is impaired during HCV and HIV infections

  3. IL-7 (zeige IL7 Proteine) has a role inducing epitope masking of gammac protein in IL-7 (zeige IL7 Proteine) receptor signaling complex

  4. The results of this study showed that IL-17 (zeige IL17A Proteine) receptor (IL-17R) were clearly up regulated in mesial temporal lobe epilepsy at both mRNA and protein levels, compared with control.

  5. the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 (zeige PTPN22 Proteine) c.1858C>T (rs2476601), TLR4 (zeige TLR4 Proteine) c.896A>G (rs4986790) and TLR4 (zeige TLR4 Proteine) c.1196C>T (rs4986791), IL7R c.197T>C (rs1494555) and IL7R c.412G>A (rs1494558).

  6. The interleukin-7 receptor alpha (IL-7Ralpha) signaling pathways are prime therapeutic targets because these pathways harbor genetic aberrations in both T-cell ALL and B-cell precursor ALL. Therapeutic targeting of the IL-7Ralpha signaling pathways may lead to improved outcomes in a subset of patients.

  7. Therefore, generalized CD8 (zeige CD8A Proteine)+ T-cell impairment in HCV infection is characterized, in part, by impaired IL-7 (zeige IL7 Proteine)-mediated signalling and survival, independent of CD127 expression. This impairment is more pronounced in the liver and may be associated with an increased potential for apoptosis. This generalized CD8 (zeige CD8A Proteine)+ T-cell impairment represents an important immune dysfunction in chronic HCV infection that may alter patient health.

  8. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (zeige TSLP Proteine) can replace IL-7 (zeige IL7 Proteine) in providing these signals.

  9. Study showed that a genetic variant in the 5' UTR of DDX39B (zeige DDX39 Proteine) reduces translation of DDX39B (zeige DDX39 Proteine) mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B (zeige DDX39 Proteine) variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.

  10. study identifies casein kinase 2 as a major player in the effects of interleukin-7 (zeige IL7 Proteine) and interleukin-7 receptor in T-cell acute lymphoblastic leukemia

Horse (Equine) Interleukin 7 Receptor (IL7R) Interaktionspartner

  1. Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.

IL7R Protein Überblick

Protein Überblick

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).

Alternative names and synonyms associated with IL7R

  • interleukin 7 receptor (IL7R)
  • interleukin 7 receptor (LOC100226205)
  • interleukin 7 receptor (Il7r)
  • CD127 Protein
  • CDW127 Protein
  • IL-7R-alpha Protein
  • IL-7RA Protein
  • IL-7Ralpha Protein
  • IL7R Protein
  • IL7RA Protein
  • ILRA Protein

Bezeichner auf Proteinebene für Interleukin 7 Receptor Proteine (IL7R)

interleukin 7 receptor , interleukin-7 receptor subunit alpha-like , IL-7 receptor alpha chain , IL-7 receptor subunit alpha , IL-7R subunit alpha , IL-7R-alpha , IL-7RA , interleukin 7 receptor alpha chain , interleukin-7 receptor subunit alpha , CD127 antigen , interleukin 7 receptor isoform H5-6 , Interleukin-7 receptor subunit alpha-like protein , Interleukin-7 receptor subunit alpha

699869 Macaca mulatta
100226205 Taeniopygia guttata
100343726 Oryctolagus cuniculus
100461835 Pongo abelii
100583768 Nomascus leucogenys
16197 Mus musculus
3575 Homo sapiens
294797 Rattus norvegicus
100034169 Equus caballus
612582 Canis lupus familiaris
521554 Bos taurus
100397720 Callithrix jacchus
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