anti-Sonic Hedgehog (SHH) Antikörper

Bezeichnung:
anti-Sonic Hedgehog Antikörper (SHH)
Auf www.antikoerper-online.de finden Sie aktuell 145 Sonic Hedgehog (SHH) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Sonic Hedgehog Proteine (96) und Sonic Hedgehog Kits (47) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 297 Sonic Hedgehog Produkte verfügbar.
Synonyme:
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh

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anti-Mouse (Murine) Sonic Hedgehog Antikörper:

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Am meisten referenzierte anti-Sonic Hedgehog Antikörper

  1. Human Polyclonal Sonic Hedgehog Primary Antibody für IF (p), IHC (p) - ABIN731108 : Weiss, Guo, Shan, Shi, Romano, Sinha, Cantley, Guo: Brg1 determines urothelial cell fate during ureter development. in Journal of the American Society of Nephrology : JASN 2013 (PubMed)
    Zeige alle 7 Referenzen für 731108

  2. Human Monoclonal Sonic Hedgehog Primary Antibody für ELISA - ABIN393243 : Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010 (PubMed)
    Zeige alle 5 Referenzen für 393243

  3. Human Monoclonal Sonic Hedgehog Primary Antibody für ELISA, WB - ABIN969395 : Dierker, Dreier, Migone, Hamer, Grobe: Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 3 Referenzen für 969395

  4. Human Monoclonal Sonic Hedgehog Primary Antibody für ELISA, FACS - ABIN4355158 : Valverde, Pereira, Dias, Guimarães, Ramos, Santos, Gurgel Rocha: Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. in Tumour biology 2016 (PubMed)
    Zeige alle 2 Referenzen für 4355158

  5. Human Monoclonal Sonic Hedgehog Primary Antibody für FACS - ABIN4897996 : Blotta, Jakubikova, Calimeri, Roccaro, Amodio, Azab, Foresta, Mitsiades, Rossi, Todoerti, Molica, Morabito, Neri, Tagliaferri, Tassone, Anderson, Munshi: Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. in Blood 2012 (PubMed)
    Zeige alle 2 Referenzen für 4897996

  6. Chicken Polyclonal Sonic Hedgehog Primary Antibody für IHC, IHC (p) - ABIN4893080 : Lozito, Tuan: Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. in Development (Cambridge, England) 2016 (PubMed)

  7. Human Monoclonal Sonic Hedgehog Primary Antibody für FACS, IHC - ABIN969567 : Kameda, Nakamura, Tanaka, Yamasaki, Kubo, Tanaka, Onishi, Katano: Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. in British journal of cancer 2010 (PubMed)

  8. Cow (Bovine) Polyclonal Sonic Hedgehog Primary Antibody für IHC, WB - ABIN2781775 : Coon, Roberts, Loscertales, Kradin: Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia. in Experimental and molecular pathology 2006 (PubMed)

Weitere Antikörper gegen Sonic Hedgehog Interaktionspartner

Mouse (Murine) Sonic Hedgehog (SHH) Interaktionspartner

  1. direct targeting of Foxf2 (zeige FOXF2 Antikörper) by Shh signaling drives cranial neural crest cell mesenchyme proliferation during upper lip morphogenesis, and disruption of this sequence results in cleft lip.

  2. Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...

  3. Expression of Bmp4 (zeige BMP4 Antikörper) in the ureteric mesenchyme depends on HH signaling and Foxf1 (zeige FOXF1 Antikörper), and that exogenous BMP4 (zeige BMP4 Antikörper) rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 (zeige FOXF1 Antikörper) function.

  4. A model in which SHH signaling plays both positive and negative roles in patterning and organogenesis of the thymus and parathyroids.

  5. This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.

  6. High SHH expression is associated with Medulloblastoma.

  7. sonic hedgehog signaling activity influences clonal spatial distribution of thalamic neurons.

  8. Both the number of lung CD31 (zeige PECAM1 Antikörper)-CD45 (zeige PTPRC Antikörper)-Sca-1 (zeige Ly6a Antikörper)+ cells and the expression levels of the Shh signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh signaling pathway are reactivated during acute adenovirus infection.

  9. We show that retinoic acid promotes, whereas SHH, acting strictly within the lingual epithelium, inhibits taste placode and lingual gland formation by thwarting RA activity.

  10. Our results suggest that Shh contributes to the development of epilepsy and suppression of its signaling prevents the development of the disease. Thus, Shh can act as a modulator of neuronal activity, rapidly regulating glutamate (zeige GRIN1 Antikörper) levels and promoting epilepsy.

Human Sonic Hedgehog (SHH) Interaktionspartner

  1. We found a novel 7q36.3 duplication involving 2 genes (SHH and RBM33) in a patient with complete corpus callosum agenesis (Figure), moderate learning difficulties, and macrocephaly

  2. Study showed that SHH expression was significantly high among breast cancer patients with advanced tumor grade, stage, nodal involvement and metastasis and this expression strongly correlated with proliferation marker.

  3. This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.

  4. YB-1 (zeige YBX1 Antikörper) is induced by Shh in CGNPs

  5. SHH siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells.

  6. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 (zeige GLI1 Antikörper) inhibitors.

  7. Data suggest that negative feedback mediated by GLI3 (zeige GLI3 Antikörper) (GLI (zeige GLI1 Antikörper)-Kruppel family member) acts to finely tune SHH (sonic hedgehog) signaling. During medulloblastoma (MB) formation, nerve tissue cells appear to express nestin (zeige NES Antikörper) which hyperactivates SHH signaling by abolishing negative feedback by GLI3 (zeige GLI3 Antikörper). Restoration of intrinsic negative feedback by repressing nestin (zeige NES Antikörper) expression represents a promising approach to treat MB. [REVIEW]

  8. The study reveals several novel individual and repetitive mutations of SHH gene in Gallbladder Cancer and Cholelithiasis samples that may be used as diagnostic markers for gallbladder carcinogenesis.

  9. Data indicate that agedunin induces its anti-metastatic effect through inhibition of sonic hedgehog protein [SHH] signaling.

  10. findings suggest that Usp7 (zeige USP7 Antikörper) is important for MB cell proliferation and metastasis by activating Shh pathway, and is a putative therapeutic target for MBs (zeige PPP1R12A Antikörper)

Xenopus laevis Sonic Hedgehog (SHH) Interaktionspartner

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (zeige DZIP1 Antikörper)-dependent stabilization of Spop (zeige SPOP Antikörper)/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 Antikörper)/Ci proteins in the Hh pathway.

  3. Notch (zeige NOTCH1 Antikörper) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (zeige BMP4 Antikörper) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (zeige IHH Antikörper) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal (zeige CAD Antikörper) boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (zeige DHCR7 Antikörper) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) Interaktionspartner

  1. study shows evolutionary alteration of a Ptch1 (zeige PTCH1 Antikörper) cis (zeige CISH Antikörper)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) Interaktionspartner

  1. Mutation of hmgcs1 (zeige HMGCS1 Antikörper) had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1 (zeige GLI1 Antikörper), a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (zeige HMGCS1 Antikörper) mutants.

  2. Shha/Smo is functionally dedicated to ray branching during fin regeneration.

  3. Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation.

  4. Time-lapse imaging revealed that knockdown of miR (zeige MYLIP Antikörper)-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR (zeige MYLIP Antikörper)-219-mediated regulation of apical Par (zeige AFG3L2 Antikörper) proteins and Shh signaling.

  5. Shh is not essential for the early activation of has2 (zeige HAS2 Antikörper), but supports proper chondrogenic differentiation.

  6. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  7. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  8. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  9. We further demonstrate that the elevated Hedgehog signaling in Sox11 (zeige SOX11 Antikörper)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (zeige SOX11 Antikörper) morphants.

  10. Pax6 (zeige PAX6 Antikörper) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

Sonic Hedgehog (SHH) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh) Antikörper
  • sonic hedgehog (SHH) Antikörper
  • sonic hedgehog (LOC100352774) Antikörper
  • sonic hedgehog (Shh) Antikörper
  • sonic hedgehog a (shha) Antikörper
  • 9530036O11Rik Antikörper
  • Dsh Antikörper
  • fc83d08 Antikörper
  • hedgehog Antikörper
  • HHG1 Antikörper
  • HLP3 Antikörper
  • HPE3 Antikörper
  • Hx Antikörper
  • Hxl3 Antikörper
  • M100081 Antikörper
  • MCOPCB5 Antikörper
  • SHH Antikörper
  • SMMCI Antikörper
  • syu Antikörper
  • TPT Antikörper
  • TPTPS Antikörper
  • vhh-1 Antikörper
  • vhh1 Antikörper
  • wu:fc83d08 Antikörper
  • Xhh Antikörper
  • xshh Antikörper

Bezeichner auf Proteinebene für anti-Sonic Hedgehog (SHH) Antikörper

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

GENE ID SPEZIES
446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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