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anti-MSH6 (MSH6) Antikörper

Bezeichnung:
anti-MutS Homolog 6 (E. Coli) Antikörper (MSH6)
Auf www.antikoerper-online.de finden Sie aktuell 143 MutS Homolog 6 (E. Coli) (MSH6) Antikörper von 21 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MSH6 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 155 MSH6 Produkte verfügbar.
Synonyme:
AU044881, AW550279, cb326, GTBP, Gtmbp, HNPCC5, HSAP, LOC100227810, p160, wu:fb36c12

Meistgesuchte Reaktivitäten zu anti-MSH6 (MSH6) Antikörper

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anti-Rat (Rattus) MSH6 Antikörper:

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anti-Mouse (Murine) MSH6 Antikörper:

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Am meisten referenzierte anti-MSH6 Antikörper

  1. Dog (Canine) Monoclonal MSH6 Primary Antibody für IF, WB - ABIN968247 : Christmann, Kaina: Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. in The Journal of biological chemistry 2000 (PubMed)
    Zeige alle 5 Referenzen für ABIN968247

  2. Human Polyclonal MSH6 Primary Antibody für IHC, IP - ABIN151795 : Masih, Kunnev, Melendy: Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA). in Nucleic acids research 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN151795

  3. Human Polyclonal MSH6 Primary Antibody für ICC, IF - ABIN151794 : Cyr, Heinen: Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN151794

  4. Human Monoclonal MSH6 Primary Antibody für EMSA, EIA - ABIN118980 : Palombo, Gallinari, Iaccarino, Lettieri, Hughes, DArrigo, Truong, Hsuan, Jiricny: GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. in Science (New York, N.Y.) 1995 (PubMed)

  5. Dog (Canine) Monoclonal MSH6 Primary Antibody für IHC (fro), IHC (p) - ABIN115272 : Schleger, Heck, Niketeghad, Schirmacher, Radaeva, Oesch, Dienes, Bannasch, Steinberg: Establishment and characterization of a nontumorigenic cell line derived from a human hepatocellular adenoma expressing hepatocyte-specific markers. in Experimental cell research 1997 (PubMed)

  6. Human Monoclonal MSH6 Primary Antibody für ELISA, WB - ABIN969292 : Becker, Creagh, ONeill: Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. in The Journal of biological chemistry 2009 (PubMed)

  7. Human Monoclonal MSH6 Primary Antibody für ICC, FACS - ABIN969293 : Grindedal, Møller, Eeles, Stormorken, Bowitz-Lothe, Landrø, Clark, Kvåle, Shanley, Maehle: Germ-line mutations in mismatch repair genes associated with prostate cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 (PubMed)

  8. Cow (Bovine) Polyclonal MSH6 Primary Antibody für IHC, WB - ABIN2776759 : Wedrén, Lovmar, Humphreys, Magnusson, Melhus, Syvänen, Kindmark, Landegren, Fermér, Stiger, Persson, Baron, Weiderpass: Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study. in BMC cancer 2009 (PubMed)

Weitere Antikörper gegen MSH6 Interaktionspartner

Zebrafish MutS Homolog 6 (E. Coli) (MSH6) Interaktionspartner

  1. Studied MSH6 gene expression in developing zebrafish and the influence of MSH6 expression on the production of mismatch binding factors.

  2. Identification and characterization of novel knockout mutants of the three major MMR (zeige MRC1 Antikörper) genes, mlh1 (zeige MLH1 Antikörper), msh2 (zeige MSH2 Antikörper), and msh6, in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 6 (E. Coli) (MSH6) Interaktionspartner

  1. human Pol alpha interacts with MSH2 (zeige MSH2 Antikörper)-MSH6 complex

  2. In colorectal neoplasms, negative expression of the MMR (zeige MRC1 Antikörper) proteins MLH1 (zeige MLH1 Antikörper), MSH2 (zeige MSH2 Antikörper) or MSH6 was seen in 15% (47 of 313) of the patients. Defect MLH1 (zeige MLH1 Antikörper) was most common and detected in 12% of the cases. Defect MLH1 (zeige MLH1 Antikörper) and MSH2 (zeige MSH2 Antikörper) were identified in each patient's normal adjacent mucosa.

  3. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 (zeige FMR1 Antikörper) gene

  4. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (zeige MLH1 Antikörper) in 40%, MSH2 (zeige MSH2 Antikörper) in 36%, MSH6 in 18% and PMS2 (zeige PMS2 Antikörper) in 6% of the families

  5. There is a positive correlation between the expressions of hMSH2 (zeige MSH2 Antikörper) and hMSH6 between males (RHO=0.673 and p=0.001) and females with colorectal adenocarcinoma.

  6. Individuals with Lynch syndrome and double-mutants in MSH6 and MSH2 (zeige MSH2 Antikörper) had normal MSH2 (zeige MSH2 Antikörper) expression, whereas MSH6 immunoexpression was lost in all evaluable cases.

  7. we identified gene promoter methylation signatures (WT1 (zeige WT1 Antikörper), MSH6, GATA5 (zeige GATA5 Antikörper) and PAX5 (zeige PAX5 Antikörper)) that are strongly correlated to, and can have a predictive value for the clinical outcome of oral squamous cell carcinoma patients

  8. In Lynch syndrome families, prostate cancer was associated with mutations in MSH6 with loss of the mismatch repair protein (zeige MSH2 Antikörper).

  9. Loss of MSH-2 (zeige MSH2 Antikörper)/MSH-6 expression was correlated with the right-colon location, poor and mucinous differentiation in colorectal adenocarcinoma.

  10. Heterozygous germline mutations in any of the mismatch repair (MMR (zeige MRC1 Antikörper)) genes, MLH1 (zeige MLH1 Antikörper), MSH2 (zeige MSH2 Antikörper), MSH6, and PMS2 (zeige PMS2 Antikörper), cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome.

Mouse (Murine) MutS Homolog 6 (E. Coli) (MSH6) Interaktionspartner

  1. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions

  2. Data suggest that MSH6 protects B cells from neoplastic transformation by preserving genomic stability.

  3. similar defects on switching in Msh2 (zeige MSH2 Antikörper)(-/-), Msh2 (zeige MSH2 Antikörper)(-/-)Msh6(-/-) and Msh2 (zeige MSH2 Antikörper)(-/-)Msh6(-/-)Msh3 (zeige MSH3 Antikörper)(-/-) mice confirm that MutSalpha but not MutSbeta plays an important role in class switch recombination

  4. Msh6 deficiency resulted in somatic instability of a (GTG (zeige GGT1 Antikörper))84 repeat.

  5. role for Msh6 in protective cellular responses of primary cells to ultraviolet-B-induced mutagenesis and, hence, the prevention of skin cancer.

  6. Data suggest that MutS homologues Msh2 (zeige MSH2 Antikörper), Msh3 (zeige MSH3 Antikörper), and Msh6 play overlapping and distinct roles during antibody diversification processes.

  7. Data suggest that activation-induced cytidine deaminase (zeige AICDA Antikörper) has limited entry points into V and S regions in vivo, and subsequent mutation requires Msh2 (zeige MSH2 Antikörper)-Msh6, but not Msh3 (zeige MSH3 Antikörper), and DNA polymerase (zeige POLB Antikörper).

  8. Mice nullizygous for both Msh2 (zeige MSH2 Antikörper) and Msh3 (zeige MSH3 Antikörper) and those nullizygous for both Msh3 (zeige MSH3 Antikörper) and Msh6 displayed the greatest overall increases in mutation frequencies compared with wild-type mice.

  9. in Msh6(-/-)Ung (zeige UNG Antikörper)(-/-) mice, mutations were mostly C,G transitions and class switch recombination was greatly reduced.

  10. p53 (zeige TP53 Antikörper) and Msh6 are functionally interrelated and these tumor suppressors act together to accelerate tumorigenesis.

MSH6 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Alternative names and synonyms associated with MSH6

  • mutS homolog 6 (E. coli) (LOC100360342) Antikörper
  • mutS homolog 6 (E. coli) (msh6) Antikörper
  • mutS homolog 6 (E. coli) (Msh6) Antikörper
  • mutS homolog 6 (E. coli) (MSH6) Antikörper
  • mutS homolog 6 (E. coli) (LOC100227810) Antikörper
  • AU044881 Antikörper
  • AW550279 Antikörper
  • cb326 Antikörper
  • GTBP Antikörper
  • Gtmbp Antikörper
  • HNPCC5 Antikörper
  • HSAP Antikörper
  • LOC100227810 Antikörper
  • p160 Antikörper
  • wu:fb36c12 Antikörper

Bezeichner auf Proteinebene für MSH6

rCG61559-like , DNA mismatch repair protein Msh6 , mutS homolog 6 (E. coli) , DNA mismatch repair protein Msh6-like , G/T mismatch-binding protein , mutS-alpha 160 kDa subunit , sperm-associated protein , g/T mismatch-binding protein , p160

GENE ID SPEZIES
100360342 Rattus norvegicus
260437 Danio rerio
366547 Rattus norvegicus
421291 Gallus gallus
459218 Pan troglodytes
100033356 Monodelphis domestica
100227810 Taeniopygia guttata
100351645 Oryctolagus cuniculus
100458732 Pongo abelii
100471984 Ailuropoda melanoleuca
100541959 Meleagris gallopavo
100562407 Anolis carolinensis
100593553 Nomascus leucogenys
2956 Homo sapiens
474585 Canis lupus familiaris
17688 Mus musculus
540526 Bos taurus
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