anti-LMO2 (LMO2) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 148 LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen LMO2 Proteine (11) und LMO2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 167 LMO2 Produkte verfügbar.
Synonyme:
LMO-2, lmo2-A, Rbtn-2, RBTN2, RBTNL1, Rhom-2, RHOM2, rhombotin-2, TTG2, wu:fc83a08, xlmo2, zgc:111930
Alle Antikörper anzeigen Gen GeneID UniProt
LMO2 16909 P25801
LMO2 362176  
LMO2 4005 P25791

Meistgesuchte Reaktivitäten zu anti-LMO2 (LMO2) Antikörper

anti-Mouse (Murine) LMO2 Antikörper:

anti-Rat (Rattus) LMO2 Antikörper:

anti-Human LMO2 Antikörper:

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Weitere Antikörper gegen LMO2 Interaktionspartner

Mouse (Murine) LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) Interaktionspartner

  1. DNM2 (zeige DNM2 Antikörper) mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 (zeige IL7 Antikörper) signalling.

  2. Hhex (zeige HHEX Antikörper) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.

  3. HHEX (zeige HHEX Antikörper) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.

  4. GATA2 (zeige GATA2 Antikörper) and Lmo2 cooperatively regulate VEGF (zeige VEGFA Antikörper)-induced angiogenesis and lymphangiogenesis via NRP2 (zeige NRP2 Antikörper).

  5. a regulatory hierarchy of HOX (zeige MSH2 Antikörper) control of LMO2 in normal development

  6. Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.

  7. A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.

  8. Studied the solution structure of Lmo2(LIM2 (zeige LHX2 Antikörper)) /Ldb1 (zeige LDB1 Antikörper)(LID) complex. Results show modular binding of tandem LIM (zeige PDLIM5 Antikörper) domains in Lmo2 to tandem linear motifs in Ldb1 (zeige LDB1 Antikörper) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.

  9. Studies demonstrate that Etv2 (zeige ETV2 Antikörper) is expressed during and required for yolk sac (zeige ADCY10 Antikörper) hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2 (zeige ETV2 Antikörper).

  10. This result raises the possibility that oncogenic Lck (zeige LCK Antikörper) may activate Lmo2 promoter through direct interaction.

Human LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) Interaktionspartner

  1. Findings suggest that LMO2 loss may be a good predictor for the presence of MYC (zeige MYC Antikörper) translocation in large B-cell lymphoma.

  2. FOXP3 (zeige FOXP3 Antikörper) binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1 (zeige TAL1 Antikörper), providing a molecular mechanism for FOXP3 (zeige FOXP3 Antikörper)-mediated transcriptional modulation in T-ALL.

  3. recurrent activating intronic mutations of LMO2, a prominent oncogene (zeige RAB1A Antikörper) in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL patient samples.

  4. Data indicate a novel functional mechanism of LMO2 in facilitating the delivery of actin monomers to the branched microfilament and increasing lamellipodia/filopodia formation in basal-type breast cancer cells.

  5. we demonstrate previously unrecognized mechanisms by which LMO2 alters human T-cell development in vivo; these mechanisms correlate with human T-ALL leukemogenesis.

  6. this study revealed a novel function of LMO2 involving in the regulatory hierarchy of UBA6 (zeige UBA6 Antikörper)-USE1 (zeige Use1 Antikörper)-FAT10ylation pathway by targeting the E1 enzyme (zeige ENOPH1 Antikörper) UBA6 (zeige UBA6 Antikörper).

  7. LMO2 is a useful marker for immunophenotypic assessment of thymic neoplasms.

  8. LMO2 was associated with increased levels of cytosolic p27(Kip1 (zeige CDKN1B Antikörper)) protein.

  9. that suppression of MIR223 expression, as compared with controls, is associated with lack of differentiation and adverse cytogenetic profile, but unrelated with LMO2 protein expression or overall survival.

  10. Alanine scanning mutagenesis of the LIM (zeige PDLIM5 Antikörper) interaction domain of LDB1 (zeige LDB1 Antikörper) revealed a discrete motif, R(320)LITR, required for LMO2 binding.

Zebrafish LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) Interaktionspartner

  1. a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure

  2. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (zeige TAL1 Antikörper)-Lmo2-induced haemangioblasts differentiate into endothelial cells

  3. Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.

  4. Scl (zeige TAL1 Antikörper)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other

LMO2 Antigen-Profil

Beschreibung des Gens

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with LMO2

  • Rhombotin-2 (rbtn2) Antikörper
  • LIM domain only 2 (rhombotin-like 1) (LOC100232598) Antikörper
  • LIM domain only 2 (Lmo2) Antikörper
  • LIM domain only 2 (rhombotin-like 1) (LMO2) Antikörper
  • LIM domain only 2 (rhombotin-like 1) (lmo2) Antikörper
  • LMO-2 Antikörper
  • lmo2-A Antikörper
  • Rbtn-2 Antikörper
  • RBTN2 Antikörper
  • RBTNL1 Antikörper
  • Rhom-2 Antikörper
  • RHOM2 Antikörper
  • rhombotin-2 Antikörper
  • TTG2 Antikörper
  • wu:fc83a08 Antikörper
  • xlmo2 Antikörper
  • zgc:111930 Antikörper

Bezeichner auf Proteinebene für LMO2

Rhombotin-2 , LIM domain only 2 (rhombotin-like 1) , LIM domain only protein 2 , LIM only 2 , LMO-2 , T-cell translocation protein 2 , cysteine-rich protein TTG-2 , rhombotin-2 , T-cell translocation gene 2 , rhombotin 2 , rhombotin-like 1 , LIM domain only-2 , ttg2 , zlmo2 , xLMO-2

GENE ID SPEZIES
100194984 Salmo salar
100232598 Taeniopygia guttata
100301679 Oncorhynchus mykiss
16909 Mus musculus
362176 Rattus norvegicus
4005 Homo sapiens
30332 Danio rerio
614876 Bos taurus
394388 Xenopus laevis
374129 Gallus gallus
609006 Canis lupus familiaris
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