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review of systematized and analyzed data on changes in PARP (zeige COL11A2 ELISA Kits) activity during development and aging of an organism, as well as data on differences in the dynamics of this activity in the presence/absence of additional stimulation and on cellular processes that are associated with activation of these enzymes.
High PARP1 expression is associated with hepatocellular carcinoma.
Up-regulation of PARP1 in the host nucleus is associated with Salmonella infection.
The mitochondrial localization of PARP1 and its intra-mitochondrial functions, with focus on cellular bioenergetics, mitochondrial DNA repair and mitochondrial dysfunction are reviewed.
These data demonstrate the presence of an FAF1 (zeige FAF1 ELISA Kits)-PARP1 axis that is involved in oxidative stress-induced (zeige SQSTM1 ELISA Kits) necrosis and in the pathology of Parkinson's disease.
Increased oxidative DNA damage in primary open angle glaucoma may be attributed to decreased expression of DNA repair enzymes, OGG1 (zeige OGG1 ELISA Kits) and PARP1, of the base excision repair pathway.
ILK (zeige ILK ELISA Kits) aids trophoblast syncytialization via downregulation of CDH1 (zeige CDH1 ELISA Kits), perhaps through an ILK (zeige ILK ELISA Kits)-PARP1-SNAI1 (zeige SNAI1 ELISA Kits) pathway
post-translational modification facilitates the mobilization of SIRT6 (zeige SIRT6 ELISA Kits) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1) to DNA break sites and for efficient repair of double-strand break.
we show that PARP-1 could play a role in the fate of human lens cells, and these first observations in human lenses suggest that it could impact on lens opacity (zeige MIP ELISA Kits). Further studies are required to elucidate the regulatory processes that give rise to these effects.
PARP1 recruits KLF4 (zeige KLF4 ELISA Kits) to activate telomerase expression and stem cell pluripotency, indicating a positive regulatory role of the PARP1-KLF4 (zeige KLF4 ELISA Kits) complex in telomerase expression in cancer and stem cells.
The present work identifies several microglial responses to the endogenous alarmin S100B (zeige S100B ELISA Kits), including release of the cytotoxic protease MMP9 (zeige MMP9 ELISA Kits) and shows that these effects are modulated by PARP-1.
flavonoids of Rosa roxburghii Tratt enhanced radioprotection at least partially by regulating PARP-1/AIF (zeige AIFM1 ELISA Kits) to reduce apoptosis.
Data indicate that poly(ADP-ribose)polymerase 1 (PARP1) D993A/D993A mice and cells are viable and show no obvious abnormalities.
Telomere-internal double-strand breaks (DSBs) are also repaired by a PARP1- and Ligase3-dependent reaction, suggesting alternative non-homologous end-joining (alt-NHEJ), which relies on microhomology at DSBs.
Data show that Tp53 (zeige TP53 ELISA Kits)- and Atm (zeige ATM ELISA Kits)-defective Chronic lymphocytic leukemia (CLL) mimicking the high-risk form of human disease and that Atm (zeige ATM ELISA Kits)-deficient CLL is sensitive to PARP1 inhibition.
The results suggest that ATRX (zeige ATRX ELISA Kits) is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.
No increase of axonal regeneration was observed in Parp1(-/-) mice after optic nerve crush injury or dorsal hemisection of the thoracic spinal cord, and there was no improvement in motor function recovery. Comprehensive in vivo analysis reveals no indication that clinical PARP inhibitors will on their own provide benefit for recovery from central nervous system trauma.
PARP1 is activated in the non-alcoholic fatty liver of mice and patients.
The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.
A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (zeige PARK2 ELISA Kits) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (zeige PARK2 ELISA Kits) mutants.
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (zeige H2AFV ELISA Kits) in a nucleosome positioned in promoter regions of PARP-1-dependent genes
Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis
PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.
Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.
PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).
demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.
PARP-e autoregulates Parp transcription
propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff
no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected
ADPRT Val762Ala and APE1 (zeige APEX1 ELISA Kits) Asp148Glu polymorphisms are not associated with increased breast cancer risk
analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites
FGF2 (zeige FGF2 ELISA Kits) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (zeige MAPK1 ELISA Kits))-dependent pathway
The transcript levels of autophagy-related genes and poly(ADP-ribose) polymerase 1 (PARP1), were transiently up-regulated by fertilization, decreased at the late 1-cell stage, and maintained until the blastocyst stage.
The PARP1 signaling pathway is involved in oocyte nest breakdown and primordial follicle formation in fetal and neonatal porcine ovaries, but is different from follicular atresia in adult porcine ovaries that involves cellular apoptosis.
Cleavage of PARP-1 by activated (cleaved) caspase-3 (zeige CASP3 ELISA Kits) may serve a key role in controlling follicular atresia through granulosa cell degeneration.
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
, ADP-ribosyltransferase NAD(+)
, ADP-ribosyltransferase diphtheria toxin-like 1
, NAD(+) ADP-ribosyltransferase 1
, poly (ADP-ribose) polymerase family, member 1
, poly [ADP-ribose] polymerase 1
, poly(ADP-ribose) polymerase
, poly(ADP-ribose) synthetase
, poly[ADP-ribose] synthase 1
, ADP-ribosyltransferase (NAD+
, ADP-ribosyltransferase 1
, ADPRT 1
, poly (ADP-ribose) polymerase)
, poly(ADP-ribose) polymerase PARP-1
, poly[ADP-ribose] synthetase 1
, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1
, Poly(ADP ribose) polymerase 1
, Poly(ADP)-Ribose polymerase
, Poly(ADP-)Ribose polymerase
, Poly(ADP-ribose) polymerase
, Poly(ADP-ribose) polymerase 1
, ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase)
, Poly[ADP-ribose] synthase 1
, LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1