anti-DIABLO (DIABLO) Antikörper

anti-Second Mitochondria-Derived Activator of Caspase Antikörper (DIABLO)
Auf finden Sie aktuell 197 Second Mitochondria-Derived Activator of Caspase (DIABLO) Antikörper von 29 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DIABLO Kits (24) und DIABLO Proteine (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 251 DIABLO Produkte verfügbar.
0610041G12Rik, 1700006L01Rik, AU040403, DBO, DFNA64, diablo-s, SMAC, smac3, XSmac
Alle Antikörper anzeigen Gen GeneID UniProt
DIABLO 56616 Q9NR28
DIABLO 288753  

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Meistgesuchte Reaktivitäten zu anti-DIABLO (DIABLO) Antikörper

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anti-Mouse (Murine) DIABLO Antikörper:

anti-Human DIABLO Antikörper:

anti-Rat (Rattus) DIABLO Antikörper:

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Am meisten referenzierte anti-DIABLO Antikörper

  1. Human Polyclonal DIABLO Primary Antibody für ICC, IF - ABIN252299 : Yoo, Kim, Kim, Park, Park, Jeon, Jung, Lee, Lee: Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas. in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003 (PubMed)
    Zeige alle 16 Referenzen für 252299

  2. Human Monoclonal DIABLO Primary Antibody für ICC, IF - ABIN153019 : Wang, Zhu, Drozda, Zhang, Stavrovskaya, Cattaneo, Ferrante, Kristal, Friedlander: Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Zeige alle 9 Referenzen für 153019

  3. Dog (Canine) Monoclonal DIABLO Primary Antibody für IF, WB - ABIN968785 : Chai, Du, Wu, Kyin, Wang, Shi: Structural and biochemical basis of apoptotic activation by Smac/DIABLO. in Nature 2000 (PubMed)
    Zeige alle 4 Referenzen für 968785

  4. Mouse (Murine) Monoclonal DIABLO Primary Antibody für ELISA, FACS - ABIN4354647 : Tikoo, OReilly, Day, Verhagen, Pakusch, Vaux: Tissue distribution of Diablo/Smac revealed by monoclonal antibodies. in Cell death and differentiation 2002 (PubMed)
    Zeige alle 3 Referenzen für 4354647

  5. Human Polyclonal DIABLO Primary Antibody für IHC, WB - ABIN223042 : Haudek, Taffet, Schneider, Mann: TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. in The Journal of clinical investigation 2007 (PubMed)
    Zeige alle 2 Referenzen für 223042

  6. Human Polyclonal DIABLO Primary Antibody für ELISA, WB - ABIN1996479 : Korga, Korobowicz, Dudka: [Role of mitochondrial protein Smac/Diablo in regulation of apoptotic pathways]. in Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 2006 (PubMed)
    Zeige alle 2 Referenzen für 1996479

  7. Cow (Bovine) Polyclonal DIABLO Primary Antibody für IHC, WB - ABIN2792127 : Samuel, Welsh, Lober, Togo, Zapata, Reed: Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. in The Journal of biological chemistry 2006 (PubMed)

  8. Human Polyclonal DIABLO Primary Antibody für IF (p), IHC (p) - ABIN674619 : Liu, Chen, Li, Wang, Cheng: Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts. in International journal of molecular medicine 2013 (PubMed)

Weitere Antikörper gegen DIABLO Interaktionspartner

Mouse (Murine) Second Mitochondria-Derived Activator of Caspase (DIABLO) Interaktionspartner

  1. We report that an Smac-mimetic selectively induces TNF-alpha (zeige TNF Antikörper)-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation.

  2. Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer.

  3. Identification of a novel anti-apoptotic E3 ubiquitin ligase (zeige MUL1 Antikörper) that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2 (zeige HTRA2 Antikörper), and ARTS.

  4. Loss of Smac/DIABLO alters both caspase (zeige CASP3 Antikörper)-dependent and caspase (zeige CASP3 Antikörper)-independent intrinsic programmed cell death.

  5. Membrane-associated XIAP (zeige XIAP Antikörper) induces mitochondrial outer membrane permeabilization leading to cytochrome c (zeige CYCS Antikörper) and Smac release, which is dependent on Bax (zeige BAX Antikörper) and Bak (zeige BAK1 Antikörper).

  6. data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function.

  7. mitochondrial activation by Bid (zeige BID Antikörper) is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release

  8. Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV.

  9. Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol.

  10. Bax (zeige BAX Antikörper) and Bak (zeige BAK1 Antikörper) differentially regulate the release of cytochrome c (zeige CYCS Antikörper) and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax (zeige BAX Antikörper) and Bak (zeige BAK1 Antikörper) genes, or resistant to TRAIL.

Human Second Mitochondria-Derived Activator of Caspase (DIABLO) Interaktionspartner

  1. Expressions of SDF-1 (zeige CXCL12 Antikörper), survivin (zeige BIRC5 Antikörper) and smac were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.

  2. Results indicate that Smac plays an important role in reticulum stress-induced apoptosis in human lens epithelial cells, suggesting its close association with cataract development.

  3. Smac mimetic APG (zeige SMAD1 Antikörper)-1387 exerts a potent antitumor effect on nasopharyngeal carcinoma cells by inducing apoptosis.

  4. These results reveal a pro-apoptotic function of PARL (zeige PARL Antikörper) and identify PARL (zeige PARL Antikörper)-mediated Smac processing and cytochrome c (zeige CYCS Antikörper) release facilitated by OPA1 (zeige OPA1 Antikörper)-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria.

  5. Study found a negative correlation between Smac and XIAP (zeige XIAP Antikörper) at the level of protein but not mRNA in non-small cell lung carcinoma (NSCLC) patients. Overexpressed XIAP (zeige XIAP Antikörper) could degrade through ubiquitination, the mature Smac inhibiting NSCLC apoptosis.

  6. Report role of RIP1 (zeige UQCRFS1 Antikörper) in Smac mimetic mediated chemosensitization of neuroblastoma (zeige ARHGEF16 Antikörper) cells.

  7. This review discusses the promise as well as some challenges at the translational interface of exploiting Smac mimetics as cancer therapeutics.

  8. Data indicate that Smac/DIABLO showed an inverse correlation with inhibitor of apoptosis proteins XIAP (zeige XIAP Antikörper), cIAP-1 (zeige BIRC2 Antikörper) and cIAP-2 (zeige BIRC3 Antikörper).

  9. Data show that mitochondrial X-linked inhibitor of apoptosis protein (XIAP (zeige XIAP Antikörper)) entry requires apoptosis regulatory proteins Bax (zeige BAX Antikörper) or Bak (zeige BAK1 Antikörper) through mitochondrial permeabilization and Smac/DIABLO protein degradation.

  10. SapC-DOPS acts through a mitochondria-mediated pathway accompanied by an early release of Smac and Bax (zeige BAX Antikörper).

Xenopus laevis Second Mitochondria-Derived Activator of Caspase (DIABLO) Interaktionspartner

  1. hyperosmotic shock induces rapid calpain activation and high levels of Smac/DIABLO release from the mitochondria before significant amounts of cytochrome c (zeige CYCS Antikörper) are released to promote caspase-3 (zeige CASP3 Antikörper) activation

  2. Identification of the third vertebrate homologue of Smac/DIABLO.

DIABLO Antigen-Profil

Beschreibung des Gens

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.

Alternative names and synonyms associated with DIABLO

  • diablo, IAP-binding mitochondrial protein (diablo) Antikörper
  • diablo homolog (Drosophila) (Diablo) Antikörper
  • diablo, IAP-binding mitochondrial protein (DIABLO) Antikörper
  • diablo, IAP-binding mitochondrial protein (Diablo) Antikörper
  • 0610041G12Rik Antikörper
  • 1700006L01Rik Antikörper
  • AU040403 Antikörper
  • DBO Antikörper
  • DFNA64 Antikörper
  • diablo-s Antikörper
  • SMAC Antikörper
  • smac3 Antikörper
  • XSmac Antikörper

Bezeichner auf Proteinebene für DIABLO

Direct IAP-binding protein with low pI , diablo homolog, mitochondrial , second mitochondria-derived activator of caspase , direct IAP binding protein with low PI , direct IAP-binding protein with low pI , diablo homolog , mitochondrial diablo-like protein , mitochondrial diablo , second mitochondrial derived activator of caspases , Second mitochondria-derived activator of caspase

549035 Xenopus (Silurana) tropicalis
66593 Mus musculus
56616 Homo sapiens
288753 Rattus norvegicus
477463 Canis lupus familiaris
100155744 Sus scrofa
493999 Bos taurus
100049147 Xenopus laevis
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