RRM2B Antikörper (N-Term)

Produktnummer ABIN966974

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-RRM2B Antikörper wird verwendet zum Nachweis von RRM2B in Proben von Human und Maus. Er wurde validiert für IHC.

Kurzübersicht für RRM2B Antikörper (N-Term) (ABIN966974)

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM2B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-RRM2B Antikörper

Bindungsspezifität: N-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human RRM2B (Ribonucleoside-diphosphate reductase subunit M2B)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-RRM2B Antikörper (ABIN966974)

Xue, Zhou, Liu, Qiu, Jin, Yen: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).

Guittet, Håkansson, Voevodskaya, Fridd, Gräslund, Arakawa, Nakamura, Thelander: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).

Yamaguchi, Matsuda, Sagiya, Iwadate, Fujino, Nakamura, Arakawa: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).

Details zu RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Andere Bezeichnung: RRM2B

Hintergrund: RRM2B (Ribonucleoside-diphosphate reductase subunit M2B) plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. RRM2B supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. RRM2B contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. RRM2B binds 2 iron ions per subunit. RRM2B interacts with p53/TP53 and interacts with RRM1 in response to DNA damage. RRM2B is widely expressed at a high level in skeletal muscle and at a weak level in thymus. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT)
Synonyms: P53R2( p53-inducible ribonucleotide reductase small subunit 2-like protein)

Pathways: p53 Signalweg, Negative Regulation of intrinsic apoptotic Signaling