PLK1 Antikörper

Produktnummer ABIN966866

Der Kaninchen Polyklonal Anti-PLK1-Antikörper wurde für IHC validiert. Er ist geeignet, PLK1 in Proben von Human, Maus und Ratte zu detektieren. Es sind 6+ Publikationen verfügbar.

Kurzübersicht für PLK1 Antikörper (ABIN966866)

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLK1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-PLK1 Antikörper

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-residues of human PLK1(Serine/threonine-protein kinase PLK1) (Polo-like kinase 1)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-PLK1 Antikörper (ABIN966866)

Jang, Ma, Terada, Erikson: "Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44115-20, (2002) (PubMed).

Wind, Kelm, Nigg, Lehmann: "Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry." in: Proteomics, Vol. 2, Issue 11, pp. 1516-23, (2002) (PubMed).

Uchiumi, Longo, Ferris: "Cell cycle regulation of the human polo-like kinase (PLK) promoter." in: The Journal of biological chemistry, Vol. 272, Issue 14, pp. 9166-74, (1997) (PubMed).

Lee, Erikson: "Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures." in: Molecular and cellular biology, Vol. 17, Issue 6, pp. 3408-17, (1997) (PubMed).

Bräuninger, Strebhardt, Rübsamen-Waigmann: "Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter." in: Oncogene, Vol. 11, Issue 9, pp. 1793-800, (1995) (PubMed).

Golsteyn, Schultz, Bartek, Ziemiecki, Ried, Nigg: "Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5." in: Journal of cell science, Vol. 107 ( Pt 6), pp. 1509-17, (1994) (PubMed).

Details zu PLK1

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Andere Bezeichnung: PLK1

Hintergrund: PLK1(Serine/threonine-protein kinase) that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. PLK1 is activated by serine and threonine phosphorylation. PLK1 interacts with CEP170 and EVI5. PLK1 interacts and phosphorylates ERCC6L. PLK1 accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase. Autophosphorylation and phosphorylation of Ser-137 are not significant events during activation of PLK1 in M phase.
Synonyms: PLK

Pathways: Zellzyklus, M Phase