SOCS1 Antikörper (Middle Region)

Produktnummer ABIN785173

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SOCS1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd und Meerschweinchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für SOCS1 Antikörper (Middle Region) (ABIN785173)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SOCS1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: RQRNCFFALS VKMASGPTSI RVHFQAGRFH LDGSRESFDC LFELLEHYVA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOCS1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SOCS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 211 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SOCS1 Antikörper (ABIN785173)

Ihedioha, Potter, Chen: "Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3." in: Innate immunity, Vol. 26, Issue 6, pp. 537-546, (2020) (PubMed).

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1

Hintergrund: SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: CSF2RB, TCEB1, ERBB2, ABL1, CYTIP, gag, TP53, JAK2, ATR, ATM, JAK1, INSR, FGFR3, LCK, RASA1, PDCD1, IRS1, ETV6, DAB1, TIRAP, VHL, VAV1, TUBG1, RELA, MAP3K5, CLEC7A, PTPN11, TYK2, IRF3, IFNAR1, TCEB2, ALK, COMMD1, TRIM8, PIK3R2, GHR, IRS2, TEC, NCK1, VAV2,
Protein Size: 211

Molekulargewicht: 23 kDa

Gen-ID: 8651

NCBI Accession: NM_003745, NP_003736

UniProt: O15524

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus