PRKACG Antikörper (AA 251-351) (Biotin)

Produktnummer ABIN751815

Der Biotin-konjugierte Kaninchen Polyklonal anti-PRKACG Antikörper (ABIN751815) detektiert spezifisch PRKACG in WB, ELISA, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PRKACG Antikörper (AA 251-351) (Biotin) (ABIN751815)

Target: PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, gamma (PRKACG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKACG Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PRKACG Antikörper (Biotin)

Bindungsspezifität: AA 251-351

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PKA gamma

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu PRKACG

Target: PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, gamma (PRKACG))

Andere Bezeichnung: PKA gamma

Hintergrund:

Synonyms: KAPG, PKA C gamma, PRKACG, Protein kinase cAMP dependent catalytic gamma, Serine threonine protein kinase, KAPCG_HUMAN.

Background: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.

Gen-ID: 5568

Pathways: AMPK Signaling, Hedgehog Signalweg, Thyroid Hormone Synthesis, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Lipid Metabolism