STAT2 Antikörper (pTyr690)

Produktnummer ABIN746183

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-STAT2 Antikörper wird verwendet zum Nachweis von STAT2 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA, ICC, IHC (p), IF (cc), IF (p) und IHC (fro).

Kurzübersicht für STAT2 Antikörper (pTyr690) (ABIN746183)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-STAT2 Antikörper

Bindungsspezifität: pTyr690

Spezifität: This phosphorylation site is homologous to that of Tyr689 in Mouse and Tyr690 in Rat.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Stat2 around the phosphorylation site of Tyr690

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-STAT2 Antikörper (ABIN746183)

Alves de Medeiros, Speeckaert, Desmet, Van Gele, De Schepper, Lambert: "JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases." in: PloS one, Vol. 11, Issue 10, pp. e0164080, (2017) (PubMed).

Details zu STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Andere Bezeichnung: Stat2

Hintergrund:

Synonyms: P113, ISGF-3, STAT113, Signal transducer and activator of transcription 2, STAT2

Background: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Gen-ID: 6773

UniProt: P52630

Pathways: JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events