phosphodiesterase 4D, CAMP-Specific (PDE4D) Antikörper (Cy5)

Antigen: phosphodiesterase 4D, CAMP-Specific (PDE4D)

Synonyme: DPDE3, STRK1, HSPDE4D, PDE4DN2, FLJ97311, DKFZp686M11213

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Konjugat: Cy5

Applikation: Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN674968

Produktbeschreibung

Weitere Bezeichnung: PDE4D

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human PDE4D

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: cAMP specific 3',5' cyclic phosphodiesterase 4D, DKFZp686M11213, FLJ97311, cAMP specific 3' 5' cyclic phosphodiesterase 4D, cAMP specific phosphodiesterase 4D, cAMP specific phosphodiesterase PDE4D, cAMP specific phosphodiesterase PDE4D6, cyclic AMP phosphodiesterase, DPDE 3, DPDE3, Dunce like phosphodiesterase E3, HSPDE4D, PDE 43, PDE43, PDE4DN2, Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3), Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila), Phosphodiesterase 4D cAMP specific, Phosphodiesterase 4D, cAMP specific (dunce), Phosphodiesterase E3 dunce homolog Drosophila, STRK 1, STRK1.

Spezifität: Excitation / Emission Wavelengths: 650nm/670nm

Molekulargewicht: 90kDa

Kommentare:

Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1

D2

D3

D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA

MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.

Anwendungen

Applikationshinweise: Flow-Cyt (1:50-200), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Signaltransduktion, Enzyme, Metabolismus

Beschränkungen: Nur für Forschungszwecke einsetzbar