LDLRAP1 Antikörper

Produktnummer ABIN645905

Der Ziege not_set anti-LDLRAP1 Antikörper wird verwendet zum Nachweis von LDLRAP1 in Proben von Human und Maus.

Kurzübersicht für LDLRAP1 Antikörper (ABIN645905)

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Reaktivität: Human, Maus

Wirt: Ziege

Konjugat: Dieser LDLRAP1 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-LDLRAP1 Antikörper

Spezifität: The goat Anti-ARH / LDL receptor antibody detects protein derived from human recombinant protein and human liver lysate at various concentrations.

Kreuzreaktivität: Human, Maus

Produktmerkmale: Goat Anti-ARH / LDL Receptor adaptor

Immunogen: Peptide with sequence C-DALKSAGRALIRS, from the N Terminus of the protein sequence according to NP_056442.1, was used as immunogen.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Supplied as 100µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Lagerung: -20 °C

Details zu LDLRAP1

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Hintergrund: LDLRAP1 is an adaptor protein that interacts with the cytoplasmic tail of low density lipoprotein receptor , phospholipids, and components of the clathrin endocytic machinery. LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR and apoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.

NCBI Accession: NP_056442

Pathways: Lipid Metabolism