FasL (CD178) Antikörper

Antigen: FasL (CD178)

Klonalität: Polyklonal

Wirt: Ziege

Applikation: ELISA, Blockierende Antikörper (Inhibition), Western Blot (WB)

Produktnummer: ABIN636623

Produktbeschreibung

Weitere Bezeichnung: FasL

Immunogen: FasL antibody was raised in goat using highly pure recombinant human FasL/Apo1L as the immunogen.

Beschreibung: Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.

Molekulargewicht: 17.6 kDa (predicted detection band MW)

Anwendungen

Reinheit: Affinity Purified

Buffer: Lyophilized from PBS, pH 7.2.

Lagerung: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C. Avoid repeated freeze/thaw cycles.

Forschungsgebiet: CD Antigene, Oberflächenrezeptoren der Immunzellen , Apoptose/Nekrose, Virologie, Krebs