Caspase 12 Antikörper (N-Term)

Produktnummer ABIN567796

Dieser Ratte Monoklonal Antikörper detektiert spezifisch Caspase 12 in WB, IF und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Caspase 12 Antikörper (N-Term) (ABIN567796)

Target: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Reaktivität: Human, Maus, Ratte

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Caspase 12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 14F4

Produktdetails anti-Caspase 12 Antikörper

Bindungsspezifität: AA 95-318, N-Term

Spezifität: This antibody reacts with Caspase-12 (~53 kDa) on Western blotting, Immunoprecipitation and Immunocytochemistry.

Aufreinigung: Protein-G Agarose Chromatography of hybridoma supernatant.

Immunogen: Recombinant Caspase-12 N-terminal fragment (aa 95-318).

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu Caspase 12

Target: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Andere Bezeichnung: Caspase-12

Hintergrund: Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-beta, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid-beta and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form.Synonyms: CASP-12, CASP12, Inactive caspase-12

Gen-ID: 100506742

NCBI Accession: NP_001177945

UniProt: Q6UXS9

Pathways: Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response