PVRL2 Antikörper (Middle Region)

Produktnummer ABIN502900

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PVRL2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Schwein.

Kurzübersicht für PVRL2 Antikörper (Middle Region) (ABIN502900)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reaktivität: Human, Maus, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PVRL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PVRL2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: MEPDGKDEEE EEEEEKAEKG LMLPPPPALE DDMESQLDGS LISRRAVYV

Homologie: Human: 100%, Mouse: 93%, Pig: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PVRL2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PVRL2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 479 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Andere Bezeichnung: PVRL2

Hintergrund: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: CD112, HVEB, PRR2, PVRR2
Protein Interaction Partner: KRTAP10-3, KRTAP10-5, KRTAP10-1, KRTAP10-7, NOTCH2NL, SIAH1, MDFI, KRTAP5-9, TIGIT, PVRL4, TNFRSF12A, PVRL3, PVRL2, LYRM4, DUS2, USP53, UBC, MAPK6, ATP5J2, PICK1, CD226, MLLT4,
Protein Size: 479

Molekulargewicht: 48 kDa

Gen-ID: 5819

NCBI Accession: NM_002856, NP_002847

UniProt: Q0MSE5

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization