Caldesmon Antikörper (Middle Region)

Produktnummer ABIN502291

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Caldesmon in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Hund, Rind (Kuh), Pferd, Kaninchen und Meerschweinchen.

Kurzübersicht für Caldesmon Antikörper (Middle Region) (ABIN502291)

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caldesmon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Caldesmon Antikörper

Bindungsspezifität: Middle Region

Sequenz: FSSPTAAGTP NKETAGLKVG VSSRINEWLT KTPDGNKSPA PKPSDLRPGD

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CALD1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CALD1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 538 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Caldesmon

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Andere Bezeichnung: CALD1

Hintergrund: CALD1 is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: CDM, H-CAD, L-CAD, MGC21352, NAG22, HCAD, LCAD
Protein Interaction Partner: TP53, RPA3, RPA2, RPA1, PHAX, FH, EPB41L2, CSNK2A1, LRCH3, PRKACA, PAN2, UBC, HSP90AA1, CALM1, ACTN1, TINF2, POT1, ISG15, TERF1, ARRB1, Poc1b, Cep76, Sass6, Pafah1b1, TERF2, SHC1, CDK1, CALM3, GRB2,
Protein Size: 538

Molekulargewicht: 63 kDa

Gen-ID: 800

NCBI Accession: NM_004342, NP_004333

UniProt: Q05682

Pathways: Myometrial Relaxation and Contraction