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TARDBP Antikörper (Center)

TARDBP Reaktivität: Human, Maus, Ratte WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500883
  • Target Alle TARDBP Antikörper anzeigen
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Bindungsspezifität
    • 15
    • 12
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 100
    • 58
    • 58
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 102
    • 14
    • 1
    Kaninchen
    Klonalität
    • 93
    • 24
    Polyklonal
    Konjugat
    • 64
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TARDBP Antikörper ist unkonjugiert
    Applikation
    • 85
    • 47
    • 34
    • 31
    • 21
    • 18
    • 14
    • 13
    • 13
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    TDP43 antibody was raised against a 18 amino acid peptide from near the center of human TDP43.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Andere Bezeichnung
    TARDBP (TARDBP Produkte)
    Synonyme
    TARDBP antikoerper, TDP43 antikoerper, DKFZp459I2127 antikoerper, tardbp antikoerper, ALS10 antikoerper, TDP-43 antikoerper, 1190002A23Rik antikoerper, C85084 antikoerper, Tdp43 antikoerper, wu:fb77f02 antikoerper, wu:fc52g10 antikoerper, TAR DNA binding protein antikoerper, Tardbp protein antikoerper, TAR DNA binding protein L homeolog antikoerper, TAR DNA-binding protein 43-like antikoerper, TARDBP antikoerper, tardbp antikoerper, tardbp.L antikoerper, Tardbp antikoerper, LOC100621383 antikoerper
    Hintergrund
    TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43
    Gen-ID
    23435
    NCBI Accession
    NP_031401
    Pathways
    Positive Regulation of Peptide Hormone Secretion
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