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TANK Antikörper (N-Term)

TANK Reaktivität: Human WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500869
  • Target Alle TANK Antikörper anzeigen
    TANK (TRAF Family Member-Associated NFKB Activator (TANK))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 55
    • 14
    • 12
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 53
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 56
    Polyklonal
    Konjugat
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TANK Antikörper ist unkonjugiert
    Applikation
    • 36
    • 26
    • 18
    • 13
    • 13
    • 13
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects TANK / ITRAF at N-term.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    TANK antibody was raised against a 14 amino acid peptide from near the amino terminus of human TANK.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    TANK (TRAF Family Member-Associated NFKB Activator (TANK))
    Andere Bezeichnung
    TANK / ITRAF (TANK Produkte)
    Synonyme
    I-TRAF antikoerper, ITRAF antikoerper, TRAF2 antikoerper, C86182 antikoerper, E430026L09Rik antikoerper, zgc:153048 antikoerper, i-traf antikoerper, tank antikoerper, traf2 antikoerper, TRAF family member associated NFKB activator antikoerper, TRAF family member-associated Nf-kappa B activator antikoerper, TRAF family member-associated NFKB activator antikoerper, TRAF family member associated NFKB activator L homeolog antikoerper, TANK antikoerper, Tank antikoerper, tank antikoerper, tank.L antikoerper
    Hintergrund
    TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex. This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins. At least two isoforms of TANK are known to exist.Synonyms: I-TRAF, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF2
    Gen-ID
    10010
    NCBI Accession
    NP_004171
    Pathways
    p53 Signalweg, TLR Signalweg, Activation of Innate immune Response
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