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TNFRSF12A Antikörper

TNFRSF12A Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499851
  • Target Alle TNFRSF12A Antikörper anzeigen
    TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
    Reaktivität
    • 43
    • 25
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 30
    • 16
    Kaninchen
    Klonalität
    • 26
    • 20
    Polyklonal
    Konjugat
    • 24
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser TNFRSF12A Antikörper ist unkonjugiert
    Applikation
    • 23
    • 13
    • 12
    • 9
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to Fn14.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.
    Isotyp
    IgG
    Top Product
    Discover our top product TNFRSF12A Primärantikörper
  • Applikationshinweise
    ELISA. Western BLot: 2-4 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
    Andere Bezeichnung
    CD266 / TweakR (TNFRSF12A Produkte)
    Synonyme
    CD266 antikoerper, FN14 antikoerper, TWEAKR antikoerper, AI255180 antikoerper, C87282 antikoerper, Fn14 antikoerper, HPIP antikoerper, TWEAK-R antikoerper, TweakR antikoerper, TNF receptor superfamily member 12A antikoerper, tumor necrosis factor receptor superfamily, member 12a antikoerper, TNFRSF12A antikoerper, Tnfrsf12a antikoerper
    Hintergrund
    TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor
    Gen-ID
    51330
    NCBI Accession
    NP_057723
    UniProt
    Q9NP84
    Pathways
    Apoptose, Regulation of Cell Size
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