TNFRSF12A Antikörper

Produktnummer ABIN499851

Der Kaninchen Polyklonal anti-TNFRSF12A Antikörper (ABIN499851) detektiert spezifisch TNFRSF12A in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TNFRSF12A Antikörper (ABIN499851)

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TNFRSF12A Antikörper

Spezifität: This antibody reacts to Fn14.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western BLot: 2-4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TNFRSF12A

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Andere Bezeichnung: CD266 / TweakR

Hintergrund: TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor

Gen-ID: 51330

NCBI Accession: NP_057723

UniProt: Q9NP84

Pathways: Apoptose, Regulation of Cell Size