Lactate Dehydrogenase A Antikörper (N-Term)

Produktnummer ABIN492379

Der Maus Monoklonal anti-Lactate Dehydrogenase A Antikörper (Klon AT1A4) (ABIN492379) detektiert spezifisch Lactate Dehydrogenase A in WB, IF und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Lactate Dehydrogenase A Antikörper (N-Term) (ABIN492379)

Target: Lactate Dehydrogenase A (LDHA)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lactate Dehydrogenase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Klon: AT1A4

Produktdetails anti-Lactate Dehydrogenase A Antikörper

Bindungsspezifität: AA 1-332, N-Term

Spezifität: The antibody recognizes Human LDHA. Other species not tested.

Produktmerkmale: Synonyms: LDH-A, L-lactate dehydrogenase A chain, LDH-M, PIG19, NY-REN-59, LDH muscle subunit,Cell proliferation-inducing gene 19 protein, Renal carcinoma antigen NY-REN-59

Aufreinigung: Affinity chromatography on Protein G

Immunogen: Recombinant human LDHA (1-332aa) purified from E. coli

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot (1: 500 - 1: 8000). Immunofluorescence (1: 500 - 1: 8000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Lactate Dehydrogenase A

Target: Lactate Dehydrogenase A (LDHA)

Andere Bezeichnung: LDHA

Hintergrund: Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.Synonyms: Cell proliferation-inducing gene 19 protein, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, NY-REN-59, PIG19, Renal carcinoma antigen NY-REN-59

Gen-ID: 3939

UniProt: P00338

Pathways: Warburg Effekt