CCDC98 Antikörper (N-Term)

Produktnummer ABIN487439

Der Maus Monoklonal anti-CCDC98 Antikörper wird verwendet zum Nachweis von CCDC98 in Proben von Human. Er wurde validiert für WB, IP, IHC (p) und FACS.

Kurzübersicht für CCDC98 Antikörper (N-Term) (ABIN487439)

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCDC98 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: ABRA1-01

Produktdetails anti-CCDC98 Antikörper

Bindungsspezifität: AA 1-313, N-Term

Spezifität: This monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Produktmerkmale: Synonyms: Protein FAM175A, ABRA1, Abraxas, Coiled-coil domain-containing protein 98, BRCA1-Acomplex subunit Abraxas

Aufreinigung: Protein A affinity chromatography

Immunogen: Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunoprecipitation. Western blot (reducing conditions).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Andere Bezeichnung: CCDC98

Hintergrund: ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A

Gen-ID: 84142

UniProt: Q6UWZ7

Pathways: DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus