ATP6V1C1 Antikörper (N-Term)

Produktnummer ABIN406715

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-ATP6V1C1 Antikörper wird verwendet zum Nachweis von ATP6V1C1 in Proben von Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für ATP6V1C1 Antikörper (N-Term) (ABIN406715)

Target: ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP6V1C1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATP6V1C1 Antikörper

Bindungsspezifität: N-Term

Sequenz: ldafvegvvk kvaqymadvl edskdkvqen llangvdlvt yitrfqwdma

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against ATP6V1C1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V1C1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 382 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ATP6V1C1 Antikörper (ABIN406715)

Meo-Evoli, Almacellas, Massucci, Gentilella, Ambrosio, Kozma, Thomas, Tauler: "V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy." in: Oncotarget, Vol. 6, Issue 29, pp. 28057-70, (2015) (PubMed).

Details zu ATP6V1C1

Target: ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))

Andere Bezeichnung: ATP6V1C1

Hintergrund: ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ATP6C, ATP6D, FLJ20057, VATC, Vma5
Protein Interaction Partner: ATP6V1C1, IVNS1ABP, ATG7, DNM1L, TSN, STAT1, SNX2, SNX1, SHMT2, SHMT1, SARS, RDX, PAWR, NASP, IDE, GTF2A1, GSPT1, CTTN, PSMG3, ANP32E, TBC1D15, SNX6, VPS35, VPS29, LUC7L2, VTA1, ARFIP1, GSPT2, UBC, UBAC2, TXNDC17, MRPS35, CISD1, VASP, TYMS, SSR1, SRSF5, A
Protein Size: 382

Molekulargewicht: 42 kDa

Gen-ID: 528

NCBI Accession: NM_001695, NP_001686

UniProt: P21283

Pathways: Transition Metal Ion Homeostasis, Proton Transport