NFKBIB Antikörper (pSer23)

Produktnummer ABIN363133

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NFKBIB in IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für NFKBIB Antikörper (pSer23) (ABIN363133)

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFKBIB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-NFKBIB Antikörper

Bindungsspezifität: pSer23

Spezifität: The antibody detects endogenous level of IkB-b only when phosphorylated at serine 23.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogen: Peptide sequence around phosphorylation site of pSer23 (L-G-S (p) -L-G) derived from Human IkB-b. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu NFKBIB

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Andere Bezeichnung: IkappaB-beta

Hintergrund: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Molekulargewicht: 48 kDa

NCBI Accession: NP_001001

UniProt: Q15653

Pathways: NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades