TRKA Antikörper (pTyr791)

Produktnummer ABIN362421

Der Kaninchen Polyklonal anti-TRKA Antikörper (ABIN362421) detektiert spezifisch TRKA in IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TRKA Antikörper (pTyr791) (ABIN362421)

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRKA Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktdetails anti-TRKA Antikörper

Bindungsspezifität: pTyr791

Spezifität: The antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogen: Peptide sequence around phosphorylation site of pTyr791 (P-V-Y (p) -L-D) derived from Human TrkA. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu TRKA

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Andere Bezeichnung: TrkA

Hintergrund: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Molekulargewicht: 140 kDa

NCBI Accession: NP_001007

UniProt: P04629

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process