TAR DNA Binding Protein (TARDBP) Antikörper

Antigen: TAR DNA Binding Protein (TARDBP)

Synonyme: ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, fb77f02, fc52g10, wu:fb77f02, wu:fc52g10, tardbp, MGC53141, TARDBP, TDP43, DKFZp459I2127, MGC129120

Klonalität: Monoklonal (K1B8)

Wirt: Maus

Reaktivität: Human

Applikation: ELISA, Western Blot (WB)

Produktnummer: ABIN361128

Produktbeschreibung

Weitere Bezeichnung: TARDBP

Immunogen: Recombinant human TARDBP (1-260aa), Accession / GI number: NP_031401

Isotyp: IgG1, kappa chain  (Passende Sekundärantikörper)

Klon: K1B8

Beschreibung: TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

Anwendungen

Applikationshinweise: Recommended dilution 1:1000(W.B), Recommended dilution 1:100(IHC)

Konzentration: 1mg/ml

Reinigung: The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography

Buffer: In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide

Lagerung: Store at -20°, Aliquot to avoid repeated freezing and thawing.

Forschungsgebiet: Hormone, Zytokine

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-TAR DNA Binding Protein (TARDBP) antibody